中文摘要：

[目的]观察引血下行中药对痰湿壅盛高血压大鼠尾动脉血压、血管紧张素Ⅱ影响。[方法]使用随机平行对照方法,将健康Wistar大鼠60只,使用随机数字表法分为6组,10只/组;空白组、模型组、卡托普利组、降压牛膝方低、中、高剂量组。除空白组外,各药物干预组均使用饮食诱导构建法复制痰湿壅盛高血压大鼠模型（高糖饲料并配合饮用1.5%Na Cl溶液）。造模第4周灌胃干预,卡托普利组：10mg/kg·d-1,1次/d;降压牛膝方低、中、高剂量：20ml/kg·d-1,2次/d;正常组及模型组：相同体积蒸馏水;连续干预6周（实验第10周）禁食12h,次日晨取腹主动脉取血。观测尾动脉血压（造模前、干预后）、血管紧张素Ⅱ。[结果]尾动脉血压（收缩压）：药物干预前（实验造模第4周）各药物干预组及模型组大鼠较空白组均显著升高（P〈0.05）,药物干预后（实验造模第10周）,各干预组均有所下降（P〈0.01,P〈0.05）,降压方牛膝中、低剂量组血压下降均低于卡托普利组（P〈0.01）;降压方牛膝中剂量组高于降压方牛膝低剂量组（P〈0.05）;降压方牛膝高剂量组降压与卡托普利无显著差异（P〉0.05）;AngⅡ水平：药物干预后（实验造模第10周）,模型组显著高于空白组（P〈0.05）,各干预组皆低于模型组（P〈0.05）;降压牛膝方高剂量组明显低于模型组（P〈0.05）,低于卡托普利组（P〈0.05）,接近空白组（P〉0.05）;降压牛膝方低剂量组与模型组无明显差异（P〉0.05）。[结论]引血下行化痰逐瘀降压牛膝方可降低痰湿壅盛高血压大鼠尾动脉血压、血管紧张素Ⅱ,且呈量效关系,高剂量组降低作用更为明显。

英文摘要：

[Objective]To observe the ＂blood lead down＂ effect in the treatment of hypertension of phlegm dampness syndrome.[Methods]60 Wistar rats were randomly divided into blank group,model group,positive control group（Kato Pury group）,semen Raphani and Achyranthes low,medium and high dose groups,10 rats in each group.Except the normal control group,each group were fed with high fat and high glucose diet and by drinking 1.5%Na Cl solution（with distilled water） method is not limited to modeling.The fourth week after modeling,the rats by intragastric administration every day.Captopril group according to 10mg/kg.d by gavage,semen Raphani semen Raphani group,high dose group and the radix Achyranthes bidentata,semen Raphani plus low dose group according to 20ml/kg.d two times distilled water by gavage,the normal group and model group were given the same volume of gastric lavage.Each medication for 6 weeks（10 weeks after modeling） after feeding is stopped for half a day,the morning of the next day to take blood pressure and vascular detection of rat angiotensin II（Ang II）.[Results]In semen Raphani add Achyranthes bidentata can reduce phlegm dampness syndrome of blood pressure and Ang II hypertension rats.[Conclusion]It is effective in the treatment of essential hypertension of phlegm dampness syndrome of blood lead down method.