中文摘要：

目的评价5种重金属暴露对秀丽线虫的生物毒性效应。方法以秀丽线虫、重金属等为关键词检索Pub Med、Web of Science、EBSCO、中国知网、万方等国内外数据库,检索时间为2004-01-2014-12,按照文献纳入和排除标准筛选关于镉（Cd）、汞（Hg）、铅（Pb）、砷（As）、铬（Cr）及铜（Cu）暴露对秀丽线虫毒性效应的文献。提取文献中相关数据,以秀丽线虫的毒性指标终点为因变量,不同金属种类、暴露浓度、暴露时间等为自变量,采用Meta回归分析比较5种重金属暴露对秀丽线虫的生物毒性效应。结果根据文献纳入和排除标准,最终筛选出有关Cu暴露对秀丽线虫生物毒性的文献10篇、有关Cr的文献12篇、有关Pb的文献12篇、有关Cd的文献10篇、有关As的文献3篇、有关Hg的文献14篇。Meta回归分析显示,以Cu为参照,5种重金属对秀丽线虫致死率排序为Hg〉Pb〉Cr〉Cd〉As,回归模型校正决定系数为0.600 8;基于发育影响的体长指标、基于生殖毒性的世代时间指标、基于神经毒性的身体弯曲度指标和头部摆动频率指标的毒性效应排序均为Hg〉Pb〉Cr〉Cd,回归模型校正决定系数分别为0.888 4、0.538 6、0.698 6和0.747 1;根据LC_（50）指标,各重金属对线虫毒性效应排序为Hg〉Pb〉Cr〉Cd〉As。敏感性分析显示,Meta回归分析结果较为稳定。结论Hg、Pb对秀丽线虫的生物毒性效应强于Cr、Cd和As。

英文摘要：

Objective To evaluate five heavy metal biotoxicity effects on Caenorhabditis elegans with Meta regression analysis.Methods The data were collected from the following electronic databases：Pub Med,Web of Science,EBSCO,the Chinese Biomedical Database,Chinese National Knowledge Infrastructure,Wan Fang（Chinese）Databases and so on,and all updated through January 2004 to December 2014.A literature review was made on articles about Cd,Hg,Pb,As and Cr toxicity effects on C.elegans,and the data was extracted from figure information by Scan It software.A Meta regression model was built by stata12.0 software,using toxicity indices such as the dependent variables,and different metals,concentrations,exposure time,and development stages of C.elegans as independent variables.Results The study articles asociated with heavy metal biotoxicity effects on C.elegans were selected out,10 studies of Cu,12 studies of Cr,12 studies of Pb,12 studies of Cd,3studies of As and 14 studies of Hg.The mortality of toxicities of 5 heavy metals on C.elegans ranked Hg Pb Cr CdAs;the biotoxicity of the indexes of body size based on development,generational time based on reproductive toxicity,body bend frequencies,and head thrash frequencies based on neurotoxicity ranked Hg Pb Cr Cd;the biotoxicity ranked Hg Pb CrCdAs by LC_（50） indexes of toxicities of 5 heavy metals on C.elegans.The sensitivity analysis proved that the Meta regression model was reliable.Conclusion The biotoxicities on C.elegans of Hg and Pb are stronger than Cr,Cd and As.