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中文摘要：
本项目以合成结构多样和功能性的含氟有机化合物为导向，发展高效、高选择性合成方法，探索碳-氢键的选择性氟化、碳-氟键的选择性断裂和可控形成的基本有机化学反应及其内在规律性；重点研究催化不对称亲电氟化反应、含氟砌块串联、多组分不对称反应等新反应、合成方法和策略及其反应规律性；开展定向合成具有特定功能的有机含氟化合物；研究含氟化合物的卤键的形成机制和规律，进一步地系统深入探讨非共价弱相互作用，为揭示其结构与功能关系的内在本质规律提供实验和理论依据，从而促进有机氟化学的发展。
英文摘要：
Organofluorine Compound；Synthesis；Reaction rule；New Method；Fluorinating agent
结论摘要：
本项目主要进行含氟有机化合物的合成、反应规律及其应用研究。针对氟化工的重要基础原料氟氯烷（烯）烃，进行了含氟分子中的碳-卤键(C-Cl, C-F, C-Br)的活化/断裂和机理的研究；开展了新含氟试剂的创制及其反应性的研究；发展温和、高效金属催化在分子中引入含氟基团的方法；利用含氟砌块的高立体选择性或区域选择性地化学转化合成在特定位置引入含氟基团的有机氟化合物，提供合成结构多样性的含氟杂环化合物的高效方法；进行不对称有机催化在有机氟化学中的应用，高立体选择性和区域选择性地合成含氟的手性化合物。含氟活泼中间体化学转化及机理研究；通过制备含氟杂环化合物并研究其分子间氢键、卤键等弱相互作用；含氟卟啉/亚卟啉的合成与性质研究。上述研究的部分结果已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nature Commun., Chem. Sci., Chem. Eur. J., Org. Lett., Chem. Commun., J. Org. Chem., Adv. Synth. Catal.等国际、国内期刊上发表论文147篇，申请中国专利10项。组织了2012, 2014年全国第十二、十四届氟化学会议，应邀参加国际、国内学术会议并做邀请报告22次。
成果综合统计
期刊论文
会议论文
专利
获奖
著作
期刊论文
Difluoromethylation and trifluoromethylation reagents derived from tetrafluoroethane β-sultone: Synt
Synthesis of 5-(Trifluoromethyl)-2,5-dihydro-1,2 lambda(5)-oxaphospholes by a One-Pot Three-Componen
Highly enantioselective [4 + 2] cycloadditions of allenoates and dual activated olefins catalyzed by
A facile synthetic route to 2-trifluoromethyl-substituted polyfunctionalized chromenes and chromones
Highly Selective Activation of Vinyl C-S Bonds Over Aryl C-S Bonds in the Pd-Catalyzed Coupling of (
Synthesis of Fullerene-Fused Fluorine-Containing Lactones from the Radical Reaction of [60]Fullerene
General and highly efficient fluorinated-N-heterocyclic carbene-based catalysts for the palladium-ca
Asymmetric intramolecular oxa-Michael reactions to tetrahydrofurans/2H- pyrans catalyzed by primary-
Impact of substituents on the luminescent properties and thermostability of Zn(II) 8-hydroxyquinolin
Br？sted acid-catalyzed electrophilic trifluoromethylthiolation of indoles using thermally stable tri
N-Trifluoromethylthiosaccharin: An Easily Accessible, Shelf-Stable, Broadly Applicable Trifluorometh
Rh-catalyzed allylic C-F bond activation: The stereoselective synthesis of trisubstituted monofluoro
Cooperative dual palladium/silver catalyst for direct difluoromethylation of aryl bromides and iodid
TiCl4-Promoted Mukaiyama Aldol Reaction of Fluorinated Silyl Enolates for the Construction of a Quat
Copper-Mediated Radical Cross-Coupling Reaction of 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123) wit
Generation of the CF3 radical from trifluoromethylsulfonium triflate and its trifluoromethylation of
Bi-functional fluoroalkylation reagents: an introduction to halo-substituted 3-oxa-perfluoroalkanesu
One-pot synthesis of trifluoromethylated phthalans via intramolecular cyclization from 2-alkynylbenz
1,3-Dipolar cycloaddition reaction of 3-trifluoromethyl-4-diazopyrazolinones with acetylenedicarboxy
Bis(perfluoroalkyl) Phosphino-Oxazoline: A Modular, Stable, Strongly pi-Accepting Ligand for Asymmet
Palladium-Catalyzed Cross-Coupling of Fluorinated Vinyl Chlorides with Terminal Alkynes: A General P
A General and Highly Selective Method for the Asymmetric Synthesis of Trifluoromethyl-Substituted al
Phosphine catalyst-controlled cycloaddition or dienylation reactions of trifluoromethyl aryl ketones
Nickel-Catalyzed alpha-Arylation of Zinc Enolates with Polyfluoroarenes via C-F Bond Activation unde
Construction of fluorinated pyrazole derivatives via a one-pot tandem C–H insertion/electrophilic fl
Enantioselective synthesis of functionalized fluorinated dihydropyrano [2,3-c]pyrazoles catalyzed by
Synthesis of alpha-Trifluoromethyl Ketones via the Cu-Catalyzed Trifluoromethylation of Silyl Enol E
Copper-Mediated Aerobic Fluoroalkylation of Arylboronic Acids with Fluoroalkyl Iodides at Room Tempe
Selective Palladium-Catalyzed C-F Activation/Carbon-Carbon Bond Formation of Polyfluoroaryl Oxazolin
Highly Selective Trifluoromethylation of 1,3-Disubstituted Arenes through Iridium-Catalyzed Arene Bo
Direct N-gem-difluorocyclopropylation of nitro-heterocycles by utilizing gem-difluorocyclopropyl tos
Ni(0) or Cu(0) catalyzed cleavage of the unactivated C-Cl bond of 2-chloro-1,1,1-trifluoroethane (HC
Three-component reactions involving quinoline or isoquinoline, dialkyl acetylenedicarboxylate and be
Polystyrene-co-poly(2,3,4,5,6-pentafluoro styrene) Copolymers: Synthesis and Fabrication of Their Po
EFFICIENT ACETYLATION OF ALCOHOLS AND PHENOLS CATALYZED BY RECYCLABLE LITHIUM BIS(PERFLUOROALKYLSULF
Structure and photophysical properties of a dimeric Zn(II) complex based on 8-hydroxyquinoline group
A facile preparation of 2-bromodifluoromethyl benzo-1,3-diazoles and its application in the synthesi
Organocatalyzed aza-Michael-Michael cascade reactions to construct spirooxindole tetrahydroquinoline
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