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中文摘要：
小分子与DNA作用机理的研究是化学生物学领域研究的热点，本项目将这项研究与化学计量学结合起来，以电分析化学方法和分子光谱方法并采用联用技术对体系进行跟踪测定，采集整个反应过程的动力学形式的多维数据。以化学计量学方法，包括平行因子法、交替最小二乘法、人工神经网络等，来解析和处理复杂生命体系的检测数据，使我们能对小分子与DNA的作用过程有更清晰的了解，包括反应的程度如何随DNA或小分子浓度变化、各阶段中存在多少种化学物质等、不同小分子之间是否存在与DNA结合的竞争和交互作用、 确定反应的平衡是否随时间而变化（包括结合点和结合常数）。同时本项目在DNA金属配合物探针和电化学分析探针方面也将作出必要的工作。本项目的意义在于找出一种深入研究小分子与DNA作用过程的新途径。该项目最大创新点在于多种仪器测试方法联用并采用化学计量学方法来处理复杂生命体系作用过程中的测量数据，实现信息的转导和提取。
结论摘要：
英文主题词DNA; BSA; Small molecular; Interaction; Chemometrics
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期刊论文
Synchronous fluorescence and UV-vis spectrometric study of the competitive interaction of chlorproma
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Simultaneous kinetic-spectrophotometric determination of three organophosphorus pesticides with mult
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Application of multivariate calibration methods for the simultaneous multiwavelength spectrophotomet
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Application of high performance liquid chromatography for the profiling of complex chemical mixtures
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