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中文摘要：
一直以来，对细胞衰老的研究都是细胞生物学和分子生物学研究的重要课题之一，倍受生物学家们的广泛关注，也因此产生了众多的细胞衰老学说，例如：端粒学说、重复基因失活学说、体细胞突变学说、衰老基因学说、代谢废弃物积累学说、大分子交联学说、自由基学说、染色体学说、基因组稳定性学说等。但迄今为止，尚未形成统一定论。衰老的发生和发展取决于多种因素，如：遗传因素、
英文摘要：
Cell aging, the fundamental unit of biological decay, is responsible for senile disease. With the development of research, the mechanism of cell aging has been investigated in molecular level. Two hypotheses have emerged to explain the reason that lamins contribute to cell aging, one is the mechanical stress hypothesis, the other is the gene expression hypothesis. The latter proposes that mutations in A - type lamins lead to abnormal tissue - specific gene regulation. In recent years, the molecular mechanisms of lamins causing cell aging primarily include gene mutation, Zmpste24 mutation, CAAX mutation and other mutations. These mutations in the gene that encode nuclear lamins cause nuclear lamina damage directly and result in cell aging, which have been associated with several degenerative disorders.
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