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中文摘要：
目的探讨stathmin基因在癫痫发病中的作用。方法取大鼠20只，随机分为对照组和青霉素组各10只。青霉素组采用腹腔注射青霉素制备大鼠癫痫模型，对照组向大鼠腹腔注射相同剂量的生理盐水。分别采用RT—PCR法和Westernblot法检测大鼠癫痫发作后脑组织中海马区stathminmRNA及蛋白表达。结果stathminmRNA及stathmin蛋白在癫痫脑组织中高表达，与对照组比较差异有统计学意义（P均〈0．05）。结论stathmin在癫痫中过表达，stathmin可能为癫痫的生物治疗提供一个新靶点。
英文摘要：
Objective To investigate the effect of stathmin gene in epilepsy. Methods Totally 20 rats were divided into penicillinum group and normal group. The epilepsy model was established by injecting penicillinum into abdominal cav- ity in penicillinum group, while the same dose of normal sodium was injected into abdominal cavity in control goup. Stathrain mRNA and protein in rat brain hippocampus tissue were examined by RT-PCR and Western blot method. Results Compared with normal group, the expression level of stathmin in the penieillinum group was higher （ P 〈0. 05）. Conclu- sion Stathmin is overexpressed in rat epilepsy brain which may be a new biotherapy target in the treatment of epilepsy.
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