中文摘要：

本文旨在探讨糖尿病足（DF）溃疡创面的临床特点及细菌谱的分布特点。采用SPSS17.0统计软件回顾性分析2012-2014年青岛市城阳人民医院内分泌科210例住院DF患者的溃疡创面临床特征、临床转归及主要病原菌分布情况,及时调整抗生素应用。结果显示,DF的诊治率逐年上升,溃疡创面显示以肌腱坏死、浅表溃疡及干湿性混合创面为主,浅表溃疡好转率最高。革兰阳性球菌感染率为56.3%,以金黄色葡萄球菌最常见,占25.0%,检出的金黄色葡萄球菌对万古霉素、利奈唑胺及莫西沙星敏感度较高（分别为100%、99%和98%）。革兰阴性杆菌感染率为39.8%,检出的大肠埃希菌及奇异变形杆菌对亚胺培南、头孢哌酮及哌拉西林敏感度较高（分别为99%、98%和95%）。本研究证实,DF溃疡创面和细菌分布复杂多样,耐药菌感染的危险因素为糖尿病病程、血糖及创面复杂性,有利于指导临床更加合理选用抗生素。

英文摘要：

The aim of this study is to investigate the clinical characteristics of diabetic foot （DF） and the profile of the isolated bacteria from DF wounds. The clinical characteristics, clinical outcomes and isolated bacteria of 210 DF cases in Chengyang People＇s Hospital of Qingdao were analyzed statistically by SPSS17.0 software. The results showed that DF morbidity was rising in the area. Tendon necrosis, superficial ulcer and dry and wet mixed wound were main manifestations. The superficial ulcer had the highest improvement rate. The infection rate of Gram-positive cocci was 56.3%. Staphylococcus aureus was the most common pathogen, accounting for 25.0%. The sensitivities of the isolated Staphylococcus aureus to vancomycin, linezolid and moxifloxacin were 100%, 99% and 98%, respectively. The infection rate of Gram-negative bacillus was 39.8%. The sensitivities of Escherichia coli and Proteus mirabilis to imipenem, cefoperazone and piperacillin were 99%, 98% and 95%, respectively. The results suggest that the distribution of bacteria in DF ulcers is complicated by multi-factors. The risk factors of drug resistance may include blood glucose, diabetes duration and complexity of the wound. This study is helpful to guide rational selection of antibiotics for DF in clinic.