中文摘要：

目的通过葡萄糖酸钙在卵巢过度刺激综合征（OHSS）高危患者取卵术后的应用来评估其在预防OHSS发生中的作用。方法选取2015年1月至2016年1月在荆州医院进行辅助生殖治疗的高危OHSS患者168例为研究对象,随机分为葡萄糖酸钙组（84例）和对照组（84例）,所有患者自取卵日开始给予10%葡萄糖500ml扩容治疗。葡萄糖酸钙组于取卵术后当日、术后第1~3天连续4d静脉滴注10%葡萄糖酸钙液10ml＋0.9%氯化钠液100ml;对照组于相同时间段静脉滴注0.9%氯化钠液100ml,观察OHSS的发生率及相关指标。结果对照组的OHSS发生率（34.52%）显著高于葡萄糖酸钙组（15.48%）（P〈0.05）,其中中度OHSS的发生率对照组（13.10%）显著高于葡萄糖酸钙组（3.57%）（P〈0.05）,而轻度OHSS、重度OHSS的发生率对照组虽高于葡萄糖酸钙组（分别为15.48%vs.9.52%、5.95%vs.2.38%）,但差异无统计学意义（P〉0.05）。结论葡萄糖酸钙能够显著降低高危OHSS患者的OHSS发生率,特别是中度OHSS的发生率。

英文摘要：

Objective： To evaluate the efficacy of calcium infusion on prevention of ovarian hyperstimulation syndrome（OHSS）in patients at high risk in IVF/ICSI treatment.Methods： A randomly prospective clinical trial including 168 patients at high risk of OHSS was performed from January 2015 to January 2016.The patients were randomly divided into two groups after oocytes pick-up（OPU）.The patients in calcium group（n=84）were intravenously administered with10 ml of 10%calcium gluconate 100ml of 0.9%saline on the OPU day,and Day1-Day3 after OPU.The patients in control group（n=84）were given with intravenous infusion of 0.9% saline 100 ml only.The incidence of OHSS and the related indexes were observed and compared between the two groups.Results： The OHSS incidence was significantly higher in the control group（34.52%）than that in the calcium infusion group（15.48%）（P〈0.05）.In which,the incidence of moderate OHSS in the control group was significantly higher（13.10%）than that in the calcium group（3.57%）（P〈0.05）.However,the incidences of mild or severe OHSS in the control group were higher than those in the calcium group,but the difference is not significantly different（15.48% vs.9.52% and 5.95% vs.2.38%,respectively）（P〉0.05）.Conclusions：Intravenous calcium infusion can effectively reduce the incidence of OHSS,especially moderate OHSS.