中文摘要：

目的：探讨早期糖尿病肾病（DN）患者应用醛糖还原酶抑制剂依帕司他（ARI）治疗后肾血流动力学参数的变化.方法：选择120例早期DN患者,分为对照组68例和治疗组52例,治疗组应用ARI治疗,对照组未应用ARI治疗,均治疗3个月.治疗前后应用彩色多普勒超声测定肾血流参数,测定生化指标,并比较2组治疗前后的临床指标及肾动脉血流动力学参数.结果：2组年龄、病程、空腹血糖、舒张压、收缩压、血清尿酸、低密度脂蛋白、三酰甘油、总胆固醇、高密度脂蛋白、腰围和体质量指数比较,差异均无统计学意义（均P〉0.05）.治疗3个月后,治疗组肾动脉和肾段动脉舒张期末血流速度（EDV）均明显高于治疗前及对照组（均P〈0.01）;治疗组肾大叶间动脉收缩期峰值血流速度及EDV均明显高于治疗前及对照组（均P〈0.01）,血流RI显著低于治疗前及对照组（均P〈0.01）.结论：ARI可改善早期DN的肾动脉血流,增加肾动脉灌注,改善肾小球微循环.

英文摘要：

Objective：To investigate the effect of early diabetic nephropathy treated with aldose reductase inhibitors/epalrestat, and observe the change of renal blood flow parameters. Methods：120 early diabetic nephropathy patients were randomly as-signed to control group and treatment group,68 and 52 cases. All patients were treated for 3 months. The control group was not treated with ARI,and the treatment group was treated with ARI,and the parameters of renal blood vessels before and after treatment were measured by color high resolution ultrasound system. SPSS 16.0 software was used for statistical treatment. Re-sults：Age,course of disease,FBG,DBP,SBP,SUA,LDL,TG,TC,HDL,WC and BMI were similar before and after the treatment, There was no significant difference （P〉0.05）. After 3 months of treatment,the treatment group of renal artery and renal artery end diastolic velocity （EDV） were significantly higher than the control group （P〈0.01）,treatment group with lobar artery peak systolic velocity （PSV） and EDV levels were significantly higher than the control group （P〈0.01）. The blood flow resistance index （RI） was significantly lower than that of the control group （P〈0.01）. Conclusion：Aldose reductase inhibitor/epalrestat can improve the blood flow of renal artery of early DN,increase renal artery perfusion,improve glomerular microcirculation,ef-fectively delay the progression of renal disease.