中文摘要：

目的探讨非肥胖男性血清脱氢表雄酮（dehydroepiandrosterone,DHEA）水平与血尿酸（serum uric acid,SUA）水平的相关性,为缺乏常规高尿酸血症危险因素的人群干预提供理论基础。方法研究对象为2012年青岛市城阳区人民医院社区流行病学调查人群,总共730名非肥胖男性人群。采用统一调查表进行问卷调查,询问吸烟饮酒及既往史。排除严重心脑肝肾疾病、糖尿病、高血压、恶性肿瘤者、吸烟、饮酒者及肥胖包括腹型肥胖者。根据SUA水平分为以下4组：SUA〈330μmol/L的人群为A组（106名）,330μmol/L≤SUA〈360μmol/L的人群为B组（173名）,360μmol/L≤SUA〈420μmol/L的人群为C组（103名）,SUA≥420μmol/L的人群为D组（348名）。记录年龄、性别,同时测量舒张压、收缩压、身高、体质量、腰围等一般指标,采集清晨空腹静脉血,测定空腹血糖、SUA、血脂、血清DHEA等指标。比较各组间血清DHEA的水平变化,通过SPSS 16.0统计软件作统计学处理。结果 （1）各组间DHEA变化趋势为A组[（13.5±1.6）μmol/L]〉B组[（9.2±1.4）μmol/L]〉C组[（5.1±1.3）μmol/L]〉D组[（1.9±1.2）μmol/L],差异有统计学意义（P〈0.05或P〈0.01）;（2）多因素相关分析显示：SUA与体质量指数（body mass index,BMI）（r=0.263,P〈0.001）、收缩压（r=0.422,P=0.02）、空腹血糖（r=0.688,P〈0.01）、三酰甘油（r=0.371,P〈0.01）、低密度脂蛋白胆固醇（r=0.346,P〈0.05）呈显著正相关,SUA与DEHA呈显著负相关（r=-0.339,P=0.04）,与年龄无相关关系（r=0.006,P=0.851）;（3）以SUA为因变量,以年龄、DHEA、BMI、腰围、收缩压、三酰甘油为自变量,进行多元线性回归,结果显示DHEA（t=-2.125,P=0.032）、BMI（t=8.261,P=0.001）、收缩压（t=6.199,P〈0.001）及三酰甘油（t=5.678,P〈0.01）进入回归方程,差异有统计学意义。结论非肥胖男性血尿酸水平与血清DHEA相关,血清DHEA逐渐降低,SUA水平?

英文摘要：

Objective To investigate relationship between serum dehydroepiandrosterone levels and serum uric acid（ SUA） in non-obese males so as to provide theoretical basis for the intervention of risk factors of hyperuricemia. Methods The objects of this study were 730 cases of non-obese men in Chengyang District People＇s Hospital of Qingdao in 2012,aged 35-75 years old（ excluding diabetes,hypertension,renal failure,etc）. According to the SUA levels,the following 4 groups were set up：group A（ 106 cases,SUA 330 μmol/L）,group B（ 173 cases,330 μmol/L ≤ SUA 360 μmol/L）,group C（ 103 cases,360 μmol/L≤SUA 420 μmol/L）,and group D（ 348 cases,SUA≥420μmol/L）. A questionnaire survey was conducted on the subjects. The history of smoking and drinking was asked. Diastolic blood pressure（ DBP）,systolic blood pressure（ SBP）,height,weight and waist circumference（ WC） were measured. Early morning fasting venous blood was collected,and fasting blood glucose（ FBG）,SUA,serum lipid and serum DHEA were determined. SPSS16. 0 statistical soft-ware was used for statistical analysis. Results The DHEA change trend was as follows： group A（ 13. 5± 1. 6） μmol/L group B（ 9. 2 ± 1. 4） μmol/L group C（ 5. 1 ± 1. 3） μmol/L group D（ 1. 9± 1. 2） μmol/L,with the difference being statistically significant among the groups（ P 0. 05 or P 0. 01）. Using the SUA as the dependent variable,and age,DHEA,BMI,WC,SBP and TG as variables,the multivariate linear regression revealed DHEA,BMI,TG and SBP entered the regression equation,and the difference was statistically significant（ t =-2. 125,8. 261,6. 199 and 5. 678,P 0. 05 or P 0. 01）. Conclusions In non-obese males,there was a correlation between SUA and serum DHEA. Serum DHEA decreased gradually,and the level of SUA increased. Simultaneously,decreased DHEA may be the risk factor of hyperuricemia. Therefore,the level of SUA in non-obese men is not only concerned with the conventional risk factors,but also should pay attention to DHEA