中文摘要：

目的观察中药溃结灵煎剂对溃疡性结肠炎（UC）结肠组织HNP1-3、NO和MDA的影响,探讨其治疗机制。方法活动期UC（大肠湿热证）患者随机分为中西药结合组（予溃结灵、SASP）与柳氮磺胺吡啶组（予SASP）,检测治疗前后肠黏膜组织内HNP1-3蛋白表达情况及结肠组织NO、MDA水平。结果随着病变程度的增加,HNP1-3、NO和MDA的表达逐渐增强,三者呈明显正相关;两组治疗后HNP1-3、NO和MDA表达较治疗前明显减少,治疗组的减少程度高于对照组。结论溃结灵配合SASP治疗能使NO和MDA对组织的细胞毒性降低,从而达到治疗溃疡性结肠炎的作用。

英文摘要：

Objective： To probe into the correlation among HNP1-3,NO and MDA and these expression in ulcerative colitis（UC） with colorectal damp heat syndrome and to observe the effect of Kuijieling Decoction in the above indices and to investigate the mechanism of Kuijieling Decociton on in UC.Methods： Patients of active UC with damp heat syndrome were randomly divided into the combination group with Kuijieling Decociton plus SASP and the control group with SASP.The HNP1-3 protein expression was detected by S-P method.The NO and the MDA were detected by the nitrate reductase method and thiobarbituric acid（TBA） coloration.Results： The expression of HNP1-3 was significantly correlated with that of NO and MDA.In the combination group and the control group,expressions such as HNP1-3,NO and MDA after the treatment were decreased significantly compared with those before the therapy.There was a remarkable difference between the combination group and the control group after treatment.Conclusion： The cytotoxicity with NO and MDA could be reduced by the combination therapy.Also,the rate and the intensity of perosidation could be decreased by this method.Moreover,the damage with histocyte could be reduced to the lowest degree so that the histocyte could be restored to treat the ulcerative colitis.