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中文摘要：
目的：对山楂核的化学成分及生物活性进行研究。方法：运用大孔吸附树脂D101,硅胶,ODS和制备高效液相色谱等方法分离化合物,通过多种波谱方法进行结构鉴定。此外,还对化合物进行了OPM2和RPMI-8226两组细胞株的细胞毒活性测试。结果：从山楂核中得到4个化合物：（7S,8S）-4-[2-hydroxy-2-（4-hydroxy-3-methoxyphenyl）-1-（hydroxymethyl）ethoxy]-3,5-dimethoxybenzaldehyde（1）,（＋）-balanophonin（2）,erythro-guaiacylglycerol-β-coniferylaldehydeether（3）,buddlenolA（4）。结论：化合物1为一新降木脂素。化合物24为属内首次分离得到。活性测试结果表明化合物14的抗肿瘤活性不明显。
英文摘要：
AIM： To study the chemical constituents and bioactivity of the seeds of Crataegus pinnatifida. METHODS： The chemical constituents were isolated and purified by macroporous adsorptive resin D101, silica gel, and ODS column chromatography, and preparative HPLC. Their structures were elucidated on the basis of spectroscopic methods. In addition, the cytotoxic activities of compounds 1-4 were investigated on OPM2 and RPMI-8226 cells. RESULTS： Four compounds were obtained and their structures were identified as （7S, 8S）-4-β-hydroxy-2-（4-hydroxy-3-methoxyphenyl）-l-（hydroxymethyl）ethoxy]-3, 5-dimethoxybenzaldehyde （1）, （＋）-balanophonin （2）, erythro-guaiacylglycerol-fl-coniferyl aldehyde ether （3）, buddlenol A （4）. CONCLUSION： Compound 1 is a novel norlignan, while compounds 1-4 exhibited marginal inhibition on the proliferation of OPM2 and RPMI-8226 cells.
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