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中文摘要：
目的综述哺乳动物肽聚糖识别蛋白（petidoglycan recognition proteins,PGRPs）的各方面特征性质及近年来研究的最新进展。方法根据已报道的30篇相关文献,按照PGRPs的发现、蛋白结构、功能及其与疾病的关系四个方面进行了总结和分类综述。结果哺乳动物肽聚糖识别蛋白家族含有4个成员,其C末端都至少含有一个约165个氨基酸残基的与噬菌体和2型细菌酰胺酶同源的PGRP结构域。PGRPs广泛分布于生物体的各个组织和器官。目前已知的PGRPs能够识别细菌、直接杀死革兰阳性菌和革兰阴性菌和具有酰胺酶活力。并且,PGRPs还跟炎症性疾病、帕金森、亚临床动脉粥样硬化等疾病相关。结论肽聚糖识别蛋白是一种重要的从无脊椎动物到脊椎动物高度保守的模式识别受体。
英文摘要：
Objective To summary the characteristics and latest research progress of the mammalian peptidoglycan recognition proteins. Methods According to the reported 30 papers,we summarize the mammalian peptidoglycan recognition proteins from the discovery of PGLYRPs,protein structure,functions and the relationship ith diseases. Results Mammals have four PGRPs-PGLYRP1,PGLYRP2,PGLYRP3,and PGLYRP4,which have at least one carboxyl-terminal PGRP domain（ contain approximately 165 amino acids residues）,which is homologous to bacteriophage and bacterial type 2 amidases. They are broadly expressed in individual tissues and organs. So far PGLYRPs recognize bacterial,are directly bactericidal for bacteria and is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial cell all peptidoglycan.There is evidence for association of PGRPs ith inflammatory diseases,Parkinson＇ s Diseases,subclinical atherosclerosis and so on. Conclusions Peptidoglycan recognition proteins is a kind of important pattern recognition receptors that are conserved from invertebrates to vertebrates.
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