中文摘要：

目的观察MMP-9、hs-CRP、BNP、S-100和DD对急性缺血性脑卒中（AIS）患者预后的影响。方法选取确诊为AIS的患者53例,检测MMP-9、hs-CRP、BNP、S-100和DD水平并进行随访,采用SAS 9.1.3统计学软件包Ka-plan-Meier法进行生存分析,采用Cox回归进行单因素分析和Cox逐步回归进行多因素分析,研究各指标对AIS预后的影响。结果单因素Cox回归分析显示,年龄和性别对AIS预后无影响（P〉0.05）;多因素Cox逐步回归分析结果显示,MMP-9、hs-CRP、BNP、S-100和DD是AIS预后的危险因素（P〈0.05）,尤其是S-100对AIS预后影响最大。结论 MMP-9、hs-CRP、BNP、S-100和DD与AIS预后密切相关,尤其以S-100影响最为显著。

英文摘要：

Objective To observe the influence of MMP-9, hs-CRP, BNP, S-100 and DD on the prognosis of patients with a- cute ischemic stroke. Methods 53 cases of patients who were diagnosed with AIS were selected. MMP9, hs-CRP, BNP, S -100 and DD levels of patients were detected and all of them were followed up. SAS 9.1.3 software and Kaplan-Meier method were adopted to analyze the survival rate; Cox regression was adopted to carry out univariate analysis and Cox step- wise regression was adopted to carry out multivariate analysis. Then the influence of various indexes in the study on the prog- nosis of AIS was researched. Results Univariate Cox regression analysis showed that age and gender had no effect on the prognosis of AIS （P 〈 0.05）; multivariate Cox stepwise regression analysis results showed that MMP-9, hs-CRP, BNP, S-100 and DD were the risk factors for the prognosis of AIS （P 〈 0.05）, especially S-100 had the biggest influence on the prognosis of AIS. Conclusion MMP-9, hs-CRP, BNP, S -100 and DD are closely related to the prognosis of AIS, especially of S-100 .