中文摘要：

目的探讨阿替普酶溶栓治疗急性缺血性脑卒中患者预后影响因素。方法选取2012年2月-2016年3月我院收治的72例急性缺血性脑卒中患者作为研究对象,回顾性分析患者的临床资料,采用多因素Logistic回归性分析所选急性缺血性脑卒中患者预后影响因素,为临床上阿替普酶溶栓治疗急性缺血性脑卒中提供参考依据。结果两组患者糖尿病史、溶栓治疗时间窗、溶栓前血糖、总胆固醇、溶栓前NIHSS评分对比有明显差异,差异有统计学意义（P〈0.05）。溶栓治疗时间窗、溶栓前血糖、溶栓前NIHSS评分均是影响患者预后的高危因素,存在明显相关性.结论严格控制患者溶栓治疗时间,降低患者溶栓前NIHSS评分及血糖,能明显提高患者溶栓治疗的有效性及安全性,对患者预后恢复有积极影响。

英文摘要：

Objective To investigate the prognostic factors of the thrombolytic therapy with alteplase in patients with acute ischemic stroke.Methods A total of 72 patients with acute ischemic stroke admitted to our hospital between March 2012 and March 2016 were retrospectively studied in order to provide reference for clinical application of alteplase thrombolytic therapy for acute ischemic stroke.The clinical data was analyzed retrospectively.Multivariate logistic regression was used to analyze the factors that might have affected the prognosis of acute ischemic stroke patients.Results Significant difference（ P〈0.05） was detected between the two groups in the history of diabetes,time of thrombolytic therapy,blood glucose before thrombolysis,total cholesterol and the NIHSS score before thrombolysis.The time window of thrombolytic therapy,blood glucose before thrombolysis,and NIHSS score before thrombolysis were all risk factors that influenced the prognosis of patients.Conclusion A vigorous control over the thrombolytic therapy time,decreasing NIHSS scores and blood glutose may significantly improve the clinical effect and safety while contributing to prognosis.