中文摘要：

支气管的气喘，最普通的过敏疾病之一，被航线 hyperresponsiveness (AHR ) 描绘，发炎，并且改变。抗氧化剂黄酮 aglycone diosmetin 改善在胰腺炎的发炎，而是很少在气喘上对它的影响被知道。在这研究，长期的气喘上的 diosmetin 的效果在航线在与 ovalbumin (卵) 质问的 BALB/c 老鼠改变的调整上与一个重音被调查。diosmetin 显著地在气喘的老鼠的肺减轻了煽动性的细胞渗入，离脚玻璃杯或瓷杯细胞增生，和骨胶原免职并且显著地在这些动物减少了 AHR，这被发现。全部的房间的导致卵的增加和在 bronchoalveolar lavage 液体的嗜曙红血球计数被颠倒，并且在浆液的卵特定的免疫球蛋白 E 的水平被 diosmetin 管理稀释，暗示 diosmetin 的一项 anti-Th2 活动。而且， diosmetin 显著地压制了光滑的肌肉肌动朊 alpha 链的表示，显示航线上的 diosmetin 的有势力 anti-proliferative 效果光滑的肌肉房间(ASMC ) 。矩阵 metallopeptidase-9，转变生长 factor-1，和脉管的 endothelial 生长因素层次是也由 diosmetin 减轻了，建议航线改变的宽恕可能被归因于这些蛋白质的衰落。一起拿，我们的调查结果向 diosmetin 的新奇侧面提供了改变反的治疗学的好处，在在长期的气喘汇寄 ASMC 增长加亮 diosmetin 的一个新潜力。

英文摘要：

Bronchial asthma, one of the most common allergic diseases, is characterized by airway hyperre- sponsiveness （AHR）, inflammation, and remodeling. The anti-oxidant flavone aglycone diosmetin ameliorates the inflammation in pancreatitis, but little is known about its impact on asthma. In this study, the effects of diosmetin on chronic asthma were investigated with an emphasis on the modu- lation of airway remodeling in BALB/c mice challenged with ovalbumin （OVA）. It was found that diosmetin significantly relieved inflammatory cell infiltration, goblet cell hyperplasia, and collagen deposition in the lungs of asthmatic mice and notably reduced AHR in these animals. The OVA- induced increases in total cell and eosinophil counts in bronchoalveolar lavage fluid were reversed, and the level of OVA-specific immunoglobulin E in serum was attenuated by diosmetin administra- tion, implying an anti-Th2 activity of diosmetin. Furthermore, diosmetin remarkably suppressed the expression of smooth muscle actin alpha chain, indicating a potent anti-proliferative effect of dios- metin on airway smooth muscle cells （ASMCs）. Matrix metallopeptidase-9, transforming growth fac- tor-β1, and vascular endothelial growth factor levels were also alleviated by diosmetin, suggesting that the remission of airway remodeling might be attributed to the decline of these proteins. Taken together, our findings provided a novel profile of diosmetin with anti-remodeling therapeutic bene- fits, highlighting a new potential of diosmetin in remitting the ASMC proliferation in chronic asthma.