多溴联苯醚(polybrominated diphenyl ethers,PBDEs)由于其良好的阻燃性能而被广泛应用于各种家用和工业产品。近年来,PBDEs及其代谢物已在各种环境介质和生物体中被广泛检出。PBDEs在生物体内易于蓄积,并可能转化为毒性更强的低溴代联苯醚、羟基-PBDEs和甲氧基-PBDEs等代谢物。该文综述了PBDEs在生物体内代谢途径、代谢机制和代谢产物的生态毒理效应。
Polybrominated diphenyl ethers (PBDEs), a specific group of brominated flame retardants, are widely used in household and industrial products, PBDEs and their metabolites have recently been reported to be present in various environmental and biotic samples. PBDEs can accumulate in organisms and be metabolized to more toxic low brominated diphenyl ether, hydroxylated PBDEs and methoxylated PBDEs. The metabolic pathways and mechanism of PBDE and the ecotoxicological effect of PBDEs metabolites were emphatically discussed in this paper.