中文摘要：

目的 探讨难治性癫痫患者中医辨证中虚证和实证与相关检查脑电图（EEG）和血清神经生长因子（NGF）的关系.方法 收集难治性癫痫患者52例,进行中医四诊检查,并辨证分型,记录患者视频脑电图结果和血清NGFs数据.结果 难治性癫痫的中医证候分为肝郁痰凝证、气滞血瘀证、心脾两虚证、肾虚精亏证;其中肝郁痰凝证、气滞血瘀证属于中医的实证范畴;心脾两虚证、肾虚精亏证属于虚证范畴.EEG结果显示虚证和实证的难治性癫痫患者脑电波有明显区别,具有明显差异（P＜0.01）;血清NGF在虚证和实证两者之间有明显差异（P＜0.05）,且虚证明显低于实证患者.结论 依据EEG结果可粗略判别出难治性癫痫的虚证和实证,实证以尖波、棘波、快波为主,虚证以慢波为主.虚证患者的NGF明显低于实证,可能与其认知和记忆功能低下有关.

英文摘要：

Objective： To investigate the relationship between deficiency and excess syndrome of TCM syndrome differentiation and intractable epilepsy and EEG as well as NGFs. Methods： 52 cases of patients with intractable epilepsy were collected and differentiated with diagnostic methods of TCM. Then the video result of EEG and NGFs data of serum were recorded. Results- TCM syndromes of intractable epilepsy are divided into the syndrome of stagnation of liver qi and phlegm, syndrome of qi stagnation and blood stasis,syndrome of deficiency of heart and spleen, deficiency of the kidney essence deficiency. The former two belong to excess syndrome, and the latter two belong to deficiency syndrome. Results： of EEG showed that there was obvious difference between the defi- ciency and excess syndrome in brain waves,with statistical difference （P〈 0.01 ）. There was discrepancy in serum NGF between deficiency syndrome and excess syndrome ,with statistical difference （P〈 0.05）,while NGF of defi- ciency syndrome patients was lower than that of excess syndrome patients. Conclusion： On the basis of the EEG, we can roughly distinguish syndromes of intractable epilepsy. Excess syndrome shows sharp spike and fast waves, while deficiency syndrome shows slow waves. NGF of Deficiency syndrome is significantly lower than that of ex- cess syndrome ,which may be related to the memory and cognitive dysfunction.