中文摘要：

[目的]制备稳定持续、简便易行的高尿酸血症动物模型。[方法]采用单纯氧嗪酸钾、氧嗪酸钾＋次黄嘌呤、腺嘌呤＋乙胺丁醇、单纯酵母膏、酵母膏＋腺嘌呤、酵母膏＋腺嘌呤＋氧嗪酸钾不同药物与不同浓度进行实验,检测模型动物血清尿酸值。[结果]单纯氧嗪酸钾、氧嗪酸钾＋次黄嘌呤模型组尿酸值升高,与空白组比较有差异,但模型不稳定,重复性差,个体差异较大。腺嘌呤＋乙胺丁醇、单纯酵母膏、酵母膏＋腺嘌呤模型组尿酸值与空白组比较无差异。酵母膏＋腺嘌呤＋氧嗪酸钾模型组尿酸值升高,与空白组比较有显著性差异（P〈0.01）,且模型稳定,个体差异小。[结论]采用酵母膏＋腺嘌呤＋氧嗪酸钾复制高尿酸血症动物模型最佳。

英文摘要：

[Objective] Preparation of stable and sustainable, simple animal model of hyperuricemia. [Methods] Using a simple oteracil potassium, oteracil potassium ＋ hypoxanthine, adenine ＋ ethambutol, pure yeast extract, yeast extract ＋ adenine, adenine ＋ yeast extract＋ oteracil potassium different drugs and different concentrations to experiment and detecting model animal serum uric acid levels.[Results] Simple oteracil potassium, potassium oxonate ＋ hypoxanthine, model group increased uric acid levels, there were differences compared with the control group, but the larger model is unstable, poor reproducibility, individual differences. Adenine ＋ ethambutol,pure yeast extract and yeast extract ＋ adenine, there was no difference between the model group and control group uric acid levels. Yeast extract ＋ adenine ＋ oteracil potassium increased uric acid levels in the model group, the control group there was a significant difference（P〈0.01）, and the model was stable, small individual differences. [Conclusion] Using yeast extract ＋ adenine ＋ oteracil potassium can copy best hyperuricemic model.