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中文摘要：
心室重构是指在各种内外因素作用下引起的左心室心肌原有结构重排,最终导致心律失常、心力衰竭,甚至心脏猝死的发生。炎症反应、心肌钙离子循环障碍和促纤维化因子释放等,都是导致心室重构的重要方面。蛋白激酶C（PKC）通过对炎症、钙离子和纤维化因子的调控,可抑制心室重构,预防猝死的发生。本文通过阐明PKC对这三个方面的调控机制,为逆转心室重构提供治疗靶点。
英文摘要：
Ventricular remodeling refers to the original structural rea- rrangement caused by left ventricular myocardial function in the various internal and external factors, may ultimately leading to arrhythmia, heart failure, and even the occurrence of sudden cardiac death. Inflammation, myocardial calcium circulatory disorder and profibrotic eytokine release are three important aspects leading to ventricular remodeling, protein kinase C （PKC） through the regulation of inflammation, calcium ion and fibrosis factor can inhibit the ventricular remodeling, and prevention of sudden death. This article want to clarify the regulation mechanism of PKC, provide a potential therapeutic target for reversing ventricular remodeling.
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