红树林内生真菌ZZF13,为湛江红树林秋茄内生真菌,种属尚未鉴定。从该菌的培养液中分离得到5个化合物,通过波谱解析以及文献对照,分别鉴定为skyrin(1),hchenxanthone(2),griseoxanthone C(3),1,3,6-三羟基8-甲基-Xanthone(4),5,7-二羟基-2-甲基色原酮(5),初步的药理活性显示,化合物1和5对Bacillus subtilis ATCC 6633的MIC分别为100和100μg/mL。
The secondary metabolites of the fungus ZZF13 were first isolated from the leaves of the mangrove sample Kandelia candel in Zhanjiang. Five compounds were isolated from the culture of this strain. They were determined to be skyrin (1), lichenxanthone (2), griseoxanthone C (3), 1, 3, 6-trihydroxy-8-methyl-gH-xanthen-9-one (4) and 5, 7-dihydroxy-2-methyl- 4H-chromen-4-one (5) by comprehensive spectroscopic analysis. Compounds 1 and 5 Showed inhibitory activities against Bacillus subtilis ATCC 6633 with MIC values of 100 和100μg/mL, respectively.