中文摘要：

目的：测定红树林共生真菌Paecilomycessp．Tree 1-7代谢产物对人肝癌细胞HepG2的杀伤作用。方法：实验分为3组：空白对照组、阳性对照组和代谢产物组，采用MTT法检测不同浓度的代谢产物对人肝癌细胞HepG2的杀伤作用。结果：代谢产物中化合物secalonic acid A对人肝癌细胞HepG2的IC50为2．0μg/ml，tenellic acid A对HepG2的IC50为62．1μg／ml，alternin对HepG2的IC50为7．0μg／ml。结论：红树林共生真菌Paecilomycessp．Tree 1-7代谢产物中secalonic acidA和alternin对人肝癌细胞HepG2具有较强的细胞毒性，值得进一步研究。

英文摘要：

Objective ： To study the cytotoxicity of the seeondary metabolites of Marine Mangrove Fungus Paecilomyces sp. Tree 1- 7 on human hepatoma cell line HepG2 cultured in vitro. Methods：Three groups were divided：compounds group,5-Fu group and control group. The cytotoxicity was measured by MTT method when HepG2 cells were treated by different concentration of the secondary metabolites of Paecilorayces sp. Tree 1-7. Results：Secalonic acid A, tenellic acid A and alternin inhibited the growth of human hepatoma cell line HepG2,the IC50 separately were 2.0,62. 1 and 7. 0 μg/ml. Conclusion：Secalonic acid A and ahernin have strong cytotoxicity on HepG2 cultured in vitro.