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中文摘要：
新近的研究提示，高迁移率族蛋白B1（high mobility group box-1 protein，HMGB1）不仅是真核生物细胞中普遍存在的非组蛋白DNA结合蛋白，还是重要的炎症因子，巨噬细胞、垂体细胞及中性粒细胞等受到炎性刺激时，都可以分泌HMGB1。严重创（烧）伤、休克及脓毒症患者血中HMGB1水平明显升高，HMGB1作为一种预警及炎症信号，可进一步影响机体的炎症及免疫反应，从而参与脓毒症发生发展的病理生理过程。
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