中文摘要：

目的 观察麝香乌龙丸联合甲氨蝶呤治疗活动期类风湿关节炎（RA）的临床疗效及其对血清中白细胞介素-1（IL-1）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）的影响。方法 将70例患者按随机数字表法分为治疗组和对照组,治疗组35例给予麝香乌龙丸联合甲氨蝶呤治疗,对照组35例给予甲氨蝶呤治疗。治疗3个月后观察两组临床疗效及IL-1、IL-6、TNF-α水平。结果 治疗后治疗组总有效率为91.42%,高于对照组的65.71%（P〈0.05）,两组治疗后血清IL-1、IL-6、TNF-α水平均有改善（P〈0.05）,治疗组较对照组改善明显（P〈0.05）。结论 麝香乌龙丸联合甲氨蝶呤能降低活动期类风湿关节炎血清中IL-1、IL-6、TNF-α的水平,明显提高其临床疗效。

英文摘要：

Objective： To observe the clinical effect of Shexiang Wulong decoction combined with methotrexate in the treatment of rheumatoid arthritis （RA） and its effect on the serum IL-1 ,IL-6 and TNF-α Methods： 70 cases of active rheumatoid arthritis patients were randomly divided into the treatment group and the control group. 35 cases in the treatment group were treated with Shexiang Wulong decoction combined with methotrexate,35 cases in the control group were treated with methotrexate. After 3 months of treatment, the clinical effect and the effect of IL-1 ,IL-6 and TNF-α in serum were observed. Results： after the treatment,the total effective rate in the treatment group was 91.42%. In the e, ontrol group,the total efficiency was 65.71%. The comparison on the serum IL-1 ,IL-6,TNF-α was statistically significant between the two groups before and after the treatment （P〈 0.05）. After the treatment,the serum IL-I,IL-6,TNF-α significantly reduced in the treatment group and showed significant difference compared with that of the control group（P〈 0.05 ）. Conclusion： Shexiang Wulong decoction combined with methotrexate can reduce the level of IL-1,IL-6 and TNF-α in the active stage of rheumatoid arthritis, and improve the clinical curative effect. It is worth to be further promoted.