尿酸性肾病,原称为痛风性肾病,是指高尿酸血症和(或)高尿酸尿症导致尿酸在肾组织沉积所造成的肾损害,主要包括痛风性肾病、尿酸性肾石病和急性肾衰竭三种类型。目前尿酸性肾病发病率逐渐升高,长期痛风而有显著性肾损害者占41%,已成为不容忽视的健康问题,中医药界对此日益重视,并开展了相关研究,取得了一些进展。在病名上,中医古代文献对痛风性肾病、尿酸性肾病无直接记载,多归属于"痛风、痹病、历节病、虚劳、腰痛、石淋"等病证的范畴。病因病机方面,脾肾亏虚,湿浊瘀血是痛风肾的病理基础,以脾肾亏虚为本,湿浊瘀血为标。在治疗上,多采取中医辨证论治,中西医结合治疗,中医专方及经验方治疗以及单味中药治疗。在实验研究方面,湿热(湿浊)、瘀血被认为是痛风肾的主要邪实病理因素,西医所说高尿酸与这些病理因素有相似之处,一些学者对于利湿化浊、活血化瘀中药在尿酸性肾病中的作用也做了研究。
Uric acid nephropathy, which is known as gouty nephropathy formerly, refers to hyperuricemia and(or) high uric acid aciduria leading to kidney damage caused by uric acid deposition in renal tissue, including gout nephropathy, uric acid nephrolithia-sis and acute renal failure. The uric acid nephropathy rate is gradually increasing, and the significant renal damage was accounted for41%. It has become a health problem, and attracted more and more attentions. Some related researches have been carried out and some progress has been made. The progress of the disease name, etiology and pathogenesis, treatment, experimental research and so on were introduced in this article.