中文摘要：

目的探讨乳腺癌患者的中医辨证分型与乳腺癌耐药蛋白(BCRP)表达的相关性。方法对80例乳腺癌患者进行术前中医辨证分型,其中血瘀证23例、肝郁证30例、脾虚证17例、肾阴虚证10例,对术后标本进行BCRP检测,并进行分析。结果乳腺癌患者术前辨证为血瘀证者BCRP表达的阳性率高于其他证型,差异有统计学意义(P<0.05)。结论乳腺癌术前中医辨证与肿瘤BCRP表达有相关性,血瘀证者BCRP表达的阳性率最高,预后差。

英文摘要：

ObjectiveTo investigate correlation between syndrome differentiation of traditional Chinese medicine and breast cancer resistance protein (BCRP) expression.MethodsThere were 80 breast cancer patients received syndrome differentiation of traditional Chinese medicine before surgery, as blood stasis syndrome group with 23 cases, hepatic depression syndrome group with 30 cases, spleen deficiency syndrome group with 17 cases, and renal yin deficiency syndrome group with 10 cases. Detection of BCRP was made on postoperative samples for analysis. ResultsPatients with blood stasis syndrome by preoperative syndrome differentiation had higher positive rate of BCRP than other types. The difference had statistical significance (P<0.05).ConclusionSyndrome differentiation of traditional Chinese medicine before breast cancer surgery is correlated with BCRP expression. Patients with blood stasis syndrome have the highest positive rate of BCRP and bad prognosis.