中文摘要：

目的探讨噪声性听力损失（NIHL）易感性与中国汉族人群SOD2rs2842980、rs5746136、rs2758331、rs4880和rs5746092单核苷酸多态性之间的关联。方法利用病例对照研究，通过比较同一噪声接触强度作业人员的左耳3000Hz频段听闯位移情况，筛选出听阈位移最大的10％个体作为易感人群组，共201例，听阈位移最小的10％个体作为耐受人群组，共202例，并进行相关的职业卫生调查和问卷调查。抽取易感人群和耐受人群空腹外周静脉血5ml用于Qiagen试剂盒抽提基因组DNA，TaqMan探针法化学荧光等位基因鉴别试验检测SNP。结果SOD2基因SNPrs4880C等位基凶是NIHL的危险因素，与T等位基因相比，OR值为1．76，95％CI为1．17～2．63，P=0．006。携带CC和CT基因型的个体患NIHL的风险是TT基因型的2．24倍，95％CI为1．43～3．50，校正混杂因素后仍可发现CC和CT基因型是NIHL的保护因素，与TT基因型相比，OR（95％CI）为2．45（1．51—3．96）。结论在中国汉族人群中，噪声性听力损失易感性与SOD2线粒体靶向定位序列的rs4880单核苷酸多态性有关。

英文摘要：

Objective To observe the association between SNPs in SOD2 and noise-induced hearing loss in Chinese HaM population. Methods A case-control study was designed to study the effect of environmental risk factors on susceptibility to NIHL in 201 sensitive workers and 202 resistant workers. A questionnaire was designed to carry out an investigation, and an occupational health survey was used to identify the occupational risk factors. Genomic DNA was extracted from peripheral blood cells samples using standard procedures of Qiagen kit. SNPs were detected using standard procedures of TaqMan probe allele identification method. Results In SOD2 gene, the C allele of rs4880 was a risk factor of NIHL, compared with the T allele, OR =1.76, 95%CI 1.17- 2.63, P=0.006. CC and CT genotypes compared with Tr were risk factors, crude OR =2.24, 95% CI 1.43- 3.50 and adjusted OR = 2.45, 95% CI 1.51 N3.96, P〈0.001, respectively. Conclusion In Chinese HaM population, SOD2 rs4880 SNP in the mitochondrial targeting sequence is associated with noise induced hearing loss.