中文摘要：

目的探讨中国汉族人群中噪声性听力损失（NIHL）易感性与超氧化物歧化酶基因（SODl）rs1041740、rs2070424、rs10432782和rs4998557单核苷酸多态性（SNP）之间的关联。方法利用病例一对照研究，通过比较同一噪声暴露强度作业人员的左耳3000Hz频段听阈位移情况，筛选出听阈位移最大的10％个体作为该研究的易感人群组，共201例；听阈位移最小的10％个体作为耐受人群组，共202例，并进行相关的职业卫生调查和问卷调查。抽取易感人群和耐受人群空腹外周静脉血5ml用于常规方法抽提基因组DNA，TaqMan探针法化学荧光等位基因鉴别试验检测SNP。结果SOD1基因rs2070424A等位基因是NIHL的保护因素，与G等位基因相比，OR值为0．67，95％C1为0．50～0．88，携带AA基因型的个体患NIHL的风险是GG基因型的0．48倍，95％CI为0．26—0．79。校正混杂因素后，OR值为0，44，95％CI为0．25～0．78。结论在中国汉族人群中，NIHL易感性与SOD1 rs2070424位点SNP有关。

英文摘要：

Objective To observe the association between SNPs in SOD1 （rs1041740, rs2070424, rs10432782 and rs4998557） and noise-induced hearing loss in Chinese Han population. Methods A case- control study was used to study the effects of environmental risk factors on the susceptibility to noise induced hearing loss （NIHL） in 201sensitive workers and 202 resistant workers. A questionnaire was designed to carry out an investigation, and an occupational health survey was used to identify the occupational risk factors. Ge- nomie DNA was extracted from peripheral blood cells using standard procedures of Takara kit, and 5 ml blood was from each subject. SNPs were detected using standard procedures of TaqMan probe allele identification method. Results In SODI gene, the A allele of rs2070424 was a protective factor of NIHL, compared with the G allele （OR=0.67, 95%CI： 0.50- 0.88）. The risk with NIHL in subjects with AA genotype was significantly lower than that in subjects with GG genotype（OR=0.48, 95%CI： 0.26-0.79）. After adjusting the confusion factors, OR was 0.44 and 95%CI was 0.25-0.78. Conclusion In Chinese Han population, the SNP of rs2070424 in SOD1 may be associated with the susceptibility to NIHL.