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中文摘要：
(HER2 ) 人的表皮的生长因素受体 2 高度在约 30% 乳癌病人被表示，并且实质的证据支持在 HER2 overexpression 和差的全面幸存之间的关系。然而， HER2 信号 transduction 小径的生物功能不是完全清楚的。在小径以内调查基因激活，我们屏蔽了差别在 HER2 积极的老鼠的表示基因用减少性的杂交与反向的弄污点的分析相结合的二方向性的抑制的乳房的肿瘤。与 transduction，房间 proliferation/growth/apoptosis 和 secreted/extracellular 矩阵蛋白质有关的四十基因和表示顺序标签是在 HER2 积极的乳房的肿瘤织物表示的差别。在这些之中， 19 已经被报导是在乳房的肿瘤表示的差别， 11 首先被识别是在这研究在乳房的肿瘤表示，但是是的差别已经在另外的肿瘤报导了，并且 10 与另外的癌症相关。这些基因能便于在乳癌发信号的 HER2 的角色的理解。
英文摘要：
Human epidermal growth factor receptor 2 （HER2） is highly expressed in approximately 30% of breast cancer patients, and substantial evidence supports the relationship between HER2 overexpression and poor overall survival. However, the biological function of HER2 signaltransduction pathways is not entirely clear. To investigate gene activation within the pathways, we screened differentially expressed genes in HER2-positive mouse mammary tumor using two-directional suppression subtractive hybridization combined with reverse dot-blotting analysis. Forty genes and expressed sequence tags related to transduction, cell proliferation/growth/ apoptosis and secreted/extracellular matrix proteins were differentially expressed in HER2-positive mammary tumor tissue. Among these, 19 were already reported to be differentially expressed in mammary tumor, 11 were first identified to be differentially expressed in mammary tumor in this study but were already reported in other tumors, and 10 correlated with other cancers. These genes can facilitate the understanding of the role of HER2 signaling in breast cancer.
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