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中文摘要：
目的：为应用药物利用评价（DUE）推动我国临床药学实践工作、促进合理用药提供参考。方法：在某实践单位建立基于DUE的抗菌药物合理使用督导工作模式并加以运行，开展头孢吡肟的利用评价和合理使用督导，同时考察其运行效果。结果：该院头孢吡肟使用的合理性得到改善，DUE评价使用理由和关键病程指征方面的指标大多有明显改善，在适应证和用药指征方面的合格率由78．6％提高到96．9％（P=0．000）；抗生素分级管理方面的合格率由60．8％提高到93．0％（P=0．000）；给药频率合格率由69．1％提高到95．0％（P=0．000）。结论：该工作模式作为一种较新的临床药学工作模式，在实践单位的运行获得良好的效果，促进了头孢吡肟的合理使用。
英文摘要：
OBJECTIVE： To provide reference for the application of drug use evaluation （DUE） to promote clinical pharmacy practice in China and rational use of drugs. METHODS ： The monitoring mode for rational use of antibacterial drugs based on DUE was established and implemented in one institution. The evaluation of cefepime use and monitoring for rational use of it were conducted. The effect of the mode was observed. RESULTS： The rationality of cefepime use had been improved in the institution. The index of drug use reasons and key disease course indicators had been improved significantly. The qualification rate of indications and drug indications increased from 78.6% to 96.9% （P=0.000）, and the qualification rate of antibacterial drugs classification management increased from 60.8% to 93.0% （P=0.000）. The qualification rate of dosing frequency increased from 69.1% to 95.0% （P=0.000）. CONCLUSION： As a new clinical pharmacy working mode, this mode plays good effect in the institution and improves the rational use of cefepime.
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