目的 探讨胃和小肠胃肠道间质瘤(GIST)患者临床病理特征的差异性.方法 经手术治疗的GIST患者164例,其中男75例,女89例,年龄50~ 70岁.比较胃及小肠GIST的临床病理特点.结果 肿瘤最常发生于胃(127例),其次为小肠(27例);肿瘤已出现肝或腹腔转移6例,淋巴结转移l例,伴发胃肠道恶性肿瘤或癌前病变8例.复发风险极低度47例,低度50例,中度24例,高度37例.胃和小肠各组的肿瘤大小、肿瘤出血、坏死、CD34表达阳性率比较,差异有统计学意义(P<0.05).结论 胃及小肠GIST的首发症状、肿瘤大小、CD34阳性率以及坏死出血概率有差异.
Objective To investigate the clinicopathological characteristics of gastrointestinal stromal tumors (GIST) located in the stomach and small intestine. Methods The clinical and imaging data of 164 patients who received surgery in Xinhua Hospital and Ruijin Hospital from June 2008 to Octo- ber 2015 and diagnosed as GIST were retrospectively analyzed. The clinicopathological characteristics of GIST occurred in the stomach and small intestine were compared for analyses. Results A total of 164 GIST patients were collected, including 75 males and 89 females. Most of the primary tumors were located in the stomach ( 127 cases), followed by the small intestine (27 cases ). There were six cases of hepatic or abdominal metastases, one case of lymphatic metastasis and eight cases associated with gastrointestinal cancer or precancerous lesions. The recurrence risk was very low in 47 cases, low in 50 cases, moderate in 24 cases and high in 37 cases. Clinicopathological analysis showed significant differences in tumor size. tumor hemorrhage, necrosis and CD34 expression between gastric and small intestinal stromal tumors ( P 〈 0.05). Conclusion Probability differences were seen between the gastric and small intestinal stromal tumors in the initial symptom, tumor size, CD34-positive rate and hemorrhagic necrosis.