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中文摘要：
组蛋白乙酰化是表观遗传修饰的重要方式，主要受到组蛋白乙酰转移酶（histone acetyhransferases，HATs）和组蛋白去乙酰化酶（histone deacetylase，HDACs）催化．MYST是人类HATs的4大家族之一，包括MOF（males absent on the first），TIP60（tat interacting protein 60 kD），结合ORC1的组蛋白乙酰转移酶（histone acetyltransferase binding to ORC1，HB01），单核细胞白血病锌指蛋白（monocytic leukemia zinc finger protein，MOZ）和MOZ相关蛋白（MOZ related factor，MORF）等，均具有典型的MYST结构域．MYST介导的乙酰化是重要的翻译后修饰，其催化底物包括组蛋白和非组蛋白，如组蛋白H3，H4，H2A，H2A突变体，以及许多参与DNA代谢、细胞增殖和发育调控的蛋白因子．MYST蛋白家族参与许多细胞的生理过程，本文主要综述其在调节基因转录、DNA损伤修复和肿瘤发生发展等方面的生物学功能．
英文摘要：
Histone acetylation is a major form of epigenetic modification catalyzed by histone acetyl transferases （HATs） and deacetylase. Human HATs are categorized 4 families, including the one with typical MYST domains, such as males absent on the first （MOF）, TAT interacting protein 60 kD （TIP60）, histone acetyhransferase binding to ORC1 （HBO1）, monocytic leukemia zinc finger protein （MOZ） and MOZ related factor （MORF）. The acetylation by MYST is an important post-translational modification that affects a large number of histone and non-histone proteins, such as histone H3, H4, H2A, H2A mutants and other protein factors involved in DNA metabolism, cell proliferation and developmental regulation. The MYST-family HATs have been implicated in fundamental cellular processes. This review discusses the MYST family proteins as an important component of gene transcription regulation, DNA repair and tumorigenesis.
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