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中文摘要：
目的探讨除草剂丁草胺对蟾蜍心肌的生理毒性。方法将中华大蟾蜍随机分为对照组、稻田组、稻田5倍组和稻田10倍组，染毒剂量分别为稻田施用浓度的1、5、10倍，即5、10、30ml／L，每组40只，分别放入盛有经曝气的自来水和试验用液的实验桶内，溶液的量为浸没1／2蟾蜍体积，分别在染毒后3、6、9d通过HE染色，观察除草剂丁草胺对蟾蜍心房肌和心室肌结构的影响；应用计算机生物信号分析系统记录心电图。结果除草剂丁草胺的染毒浓度影响蟾蜍心肌细胞的结构，随染毒浓度增加，心肌细胞出现不同程度的坏死；随着除草剂丁草胺浓度的增加和染毒时间的递增，心电图发生改变，各波振幅变化较时间变化明显，P-R间期和Q-T间期变化显著，以染毒时间的影响更明显。结论除草剂丁草胺能影响蟾蜍心肌细胞的结构和心电图。
英文摘要：
Objective To study the toxicity of herbicide, butachlor, to myocardium of Bufo bufo gargarizans. Methods One hundred and sixty Bufo bufo gargarizans were randomly divided into control group, paddy goup,5 times paddy group,10 times paddy group, forty in each group and the exposure was conducted in the experimental containers at the concentrations of 1,5,10 times of the application dosages （ 5,10,30 ml/L）, 1/2 of the body of Bufo bufo gargarizans was immersed in the sulotion. After 3,6,9 days of exposure, electrocardiogram was recorded using calculator living creature signal analysis system and the structures of atrium muscle and ventricles muscle were observed with HE stain. Results The structure of myocardial cells of Bufo bufo gargar/zarts was damaged by butachlor with different levels. Pathological examination showed that the myocardial cells appeared necrosis in different degrees with the increasing doses of butachlor. Butachlor could affact the eletrocardiogram of Bufo bufo gargarizans with obvious dose-time- dependent manner, time-dependent manner was even dominant. Abnormal electrocardiogram was seen, P-R and Q-T changed. Conclusion Butachlor exposure can damage the structure and eletrocardiogram of myocardial cell in Bufo bufo gargarizans.
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