中文摘要：

目的 评价抗氨基甲酰化蛋白（CarP）抗体在RA诊断中的应用价值.方法 收集2015年9月1日至2016年6月1日就诊于宁夏医科大学总医院风湿免疫科关节疼痛的247例住院患者的临床资料及实验室检查结果,依据最终确诊结果分为RA组（病例组）126例和非RA组（对照组）121例,ELISA法测定各组血清抗CarP抗体浓度,并同期检测RF及抗CCP抗体;应用Mann-Whitney U检验进行统计学分析,采用受试者工作特征曲线（ROC）确定抗CarP抗体对RA诊断的最佳截断值并分析其诊断效能.结果 通过绘制ROC曲线显示抗CarP抗体对RA诊断的最佳截断值为63.77 U/ml,灵敏度为74.60％,特异度为71.07％.与RF及抗CCP抗体相比,ROC曲线下面积（A）由大到小分别是：抗CCP抗体（0.88）〉ARF（0.85）〉A抗CarP抗体（0.78）,其中A抗CCP抗体与ARE、ARE与A抗CarP抗体面积间差异无统计学意义（Z=1.29,P=0.20;Z=1.30,P=0.20）,A抗CCP抗体与A抗CarP抗体面积间差异具有统计学意义（Z=2.28,P=0.02）.结论 抗Carp抗体在RA的诊断中具有一定的价值,可作为RA诊断的血清学指标.

英文摘要：

Objective To evaluate the value of anti-carbamylated protein （CarP） antibody in the diagnosis of rheumatoid arthritis （RA）.Methods The clinical data and serum of 247 in-patients with joint pain of Department of Rheumatology,General Hospital of Ningxia Medical University admitted during September 1,2015 to June 1,2016 were collected and divided into two groups according to the final diagnosis：RA group （case group） which included 126 patients and the non-RA group which included 121 patients （control group）.The concentration of anti-CarP antibody in serum was measured by enzyme linked immunosorbent assay （ELISA）.The serum rheumatoid factor （RF） and anti-cyclic citrullinated peptide （CCP） antibodies were detected at the same time.Mann-Whitney U nonparametric test for statistical analysis,receiver operating characteristic curve （ROC） was drawn to determine the cut-off value of anti-CarP antibody to RA diagnosis and to analyze its diagnostic efficacy.Results The ROC curve showed that the anti-CarP antibody had a cutoff value of 63.77 U/ml,with the sensitivity of 74.60%,and specificity of 71.07%.Compared with RF and anti-CCP antibody,the area under the ROC curve （A） were：Aanti-cyclic citrullinted peptide（anti-CCP）antibody （0.88）〉ARF （0.85）〉Anti-CarP antibody （0.78）.There was no significant difference between the Aanti-CCP antibodies and ARF as well as ARF and Aanti-CarP antibodies （Z=1.29,P=0.20;Z=1.30,P=0.20）,but there was significant difference between Aanti-CCP antibody and A anti Carp antibody （Z=2.28,P=0.02）.Conclusion Anti-CarP antibody has certain value in the diagnosis of RA,and can be used as the serological index for RA diagnosis.