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中文摘要：
为揭示不同发育阶段山羊小肠黏膜免疫特点的内在规律，本试验采用组织学和组织化学方法，对0．5、2和12月龄山羊小肠不同肠段的上皮内淋巴细胞、杯状细胞和肥大细胞的分布和数量变化进行了比较研究。结果显示：随着年龄增长，小肠各段上皮内淋巴细胞和肥大细胞的数量逐步增多（P〈0．05），而杯状细胞却逐渐减少（P〈0．05）。上皮内淋巴细胞数从十二指肠至回肠逐渐减少，0．5月龄的回肠上皮内淋巴细胞数仅是十二指肠和空肠的84．45％和98．14％（P〈0．05），肥大细胞的分布规律与上皮内淋巴细胞相似；相反，杯状细胞数从十二指肠至回肠逐渐增多。以上结果提示，在山羊小肠的早期发育中，杯状细胞起着重要的黏膜屏障功能，随着肠道黏膜免疫系统的发育，上皮内淋巴细胞和肥大细胞的黏膜防御作用进一步增强。
英文摘要：
In order to reveal the underlying rules of small intestinal mucosal immunity in goat at different developing stages, 0.5, 2 and 12 months, respectively, the distribution and number changes of intraepithelial lymphocytes （IELs）, goblet cells （GCs） and mast cells （MCs） were investigated by histological and histochemical methods. The results showed that the number of IELs and MCs were significantly increased （P〈0.05） with age, while the number of GCs decreased substantially （P〈0.05）. On the other hand, the distribution of IELs was decreased from duodenum to ileum, and the number of IELs in duodenum and jejunum was 84.45% and 98.14% of ileum respectively at 0.5 month old. The distribution of MCs was similar to that of IELs. The number of GCs, however, increased from duodenum to ileum. The results suggested that GCs played a crucial defensive barrier role in the early postnatal period, while the effect of IELs and MCs enhanced concomitant with postnatal development of the gut mucosal immune system.
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