目的研究云南松松塔提取物对正常小鼠免疫功能的影响.方法:昆明种小鼠灌胃给予高、中、低剂量(400、200、100mg/kg)的松塔提取物,阳性对照药左旋咪唑(25 mg/kg),连续给药10 d后,处死小鼠,测定小鼠血清中免疫球蛋白IgA、IgM、IgG和补体C3、C4的含量,测全外周血细胞数,计算脾脏指数和胸腺指数.结果:云南松松塔提取物能增加外周血中的免疫球蛋白IgA、IgM、补体C4的含量和白细胞数,与正常组相比差异均具有统计学意义(P 〈0.05).结论:云南松松塔提取物对正常小鼠的免疫功能有-定的增强作用.
Objective To study the effect of pinecone extract of Pinus Yunnanensis on immune function of normal mice. Methods:Kunming mice were administered high, middle and low dose of pinecone extract(400,200,100 mg/kg), 25 mg/kg Levamisole by gavageand the mice were sacrificed after 10 days. The content of immunoglobulin IgA, IgM, IgG, complement C3 and C4 in mice serum wasmeasured; the amount of peripheral blood cell, spleen index, and thymus index were measured as well. Results: The pinecone extractof Pinus Yunnanensis could increase immunoglobulin IgA, IgM, complements C4 and WBC in peripheral blood content. Compared withnormal group, the difference reflects statistical significance(P 〈0.05). Conclusion: The pinecone extract of Pinus Yunnanensis canenhance the immune function of normal mice .