中文摘要：

目的通过PFNET分析并结合可视化的方式,研究国内外先天性心脏病（CHD）介入诊断治疗研究主题的结构分布,比较国内外该学科研究主题异同,寻找中国研究的优势和薄弱环节。方法 2011年3月以MeSH词＂heart defects,congenital＂,＂cardiac catheterization＂在Medline数据库,以主题词＂心脏缺损,先天性＂,＂心脏导管插入术＂在中国生物医学文献数据库（CBM）中检索文献。确定英文核心关键词60个,词频〉90次;中文核心关键词53个,词频〉20次。使用Endnote X4软件提取关键词,建立共词矩阵。进行PFNET分析确立主题结构,并根据主题分布计算外部链接强度。使用Ucinet6.0软件绘制可视化网络。结果 Medline和CBM分别命中文献3000篇和1015篇。成功建立国内外CHD介入诊断治疗研究主题结构图谱;国内外研究的进步均以临床治疗需求为原始驱动力;国外研究起步较早,其研究主题较中国更为丰富,研究更为充分;中国的介入治疗研究相对较为独立,与外科治疗间合作较少;中国研究虽然较国外起步晚,但已形成自己的研究特色。结论基于PFNET分析的可视化研究系统、全面和直观地揭示了国内外CHD介入诊断治疗研究主题的发展态势,为相关临床研究发展提供参考。

英文摘要：

Objective To investigate and compare the research topics of interventional diagnosis and therapy of congenital heart disease （CHD） through visualized structure networks based on path finder network （PFNET） analysis at home and abroad, point out the advantage and weakness of the native studies in this field. Methods Medline database and China Biology Medicine disc （CBM） using MeSH keywords ＂heart defect, congenital＂ and ＂cardiac catheterization＂ were searched in March, 2011. After core key words had been charactered by Endnote X4 software, the co-occurrence matrix was built. After that, PFNET analysis was completed, leading the outside linking strength to be calculated. Then draw visualized network in Ucinet 6.0 software. Results The search results included 3 000 and 1 015 articles in each database, which were imported into Endnote X4 software. The visualized structure of research topics was successfully built, and the structural differences between native and overseas researches were directly reflected. Clinic demands were the original driving force in both native and oversea research developments. The overseas research topics were more sufficient and fully developed, while the native researches showed more independent with less connection with open surgical procedure. And the characteristics of native researches were formed during the past 30 years with high speed development. Conclusions Visualized structure networks based on PFNET analysis provide a systemic study about research topics of interventional diagnosis and therapy of CHD, intuitively illustrate the connections and developmental trends of the research topics in this field.