目的 总结并分析听神经病患者最大言语识别率与其他客观测听结果之间的相关性,探讨最大言语识别率在诊断听神经病中的意义。方法 106例(212耳)听神经病患者均进行最大言语识别率、畸变产物耳声发射、听性脑干反应测试、耳蜗电图、40Hz事件相关电位、听性稳态反应测试,分析主客观听力测试与最大言语识别率测试的关系。应用PASW Statistics 18.0统计软件处理数据。结果 听神经病患者最大言语识别率较好组与较差组中轻度到重度听力损失均有出现,PBmax程度在总体水平上与听力损失程度和听力曲线类型相关;PBmax程度与镫骨肌反射之间具有统计学意义,引出或部分引出声反射耳总体水平好于未引出声反射耳;ABR检查212耳中,仅有12耳能引出重复性不佳的ABR波,引出波形比例为5.7%(12/212),阈值均≥80d Bn HL,ABR可记录到波形组的PBmax程度显著好于ABR无反应组(P〈0.05);-SP/AP比值在PBmax不同组别之间,其PBmax具有显著性差异(P〈0.05),-SP/AP〈0.5组及比值介于0.5-1.0组的患耳PBmax程度最好,-SP/AP比值〉1时程度较差。PBmax与40Hz事件相关电位、听性稳态反应阈值呈负相关(P〈0.05)。结论 听神经病患者最大言语识别率与主客观听力学特征密切相关,PBmax的测试水平是听觉通路上不同病变部位功能障碍或缺失的综合反映,间接体现了AN患者从周边到中枢一系列非同步化反应的变化。PBmax联合主客观听力测试对分析听神经病病变部位,判断病变程度具有重要的临床参考价值。
Objective to summarize and analyze the correlation between maximum speech recognition score(PBmax) and other objective or subjective audiometry testing results of auditory neuropathy patients, and to find out the importance for diagnosis. Methods All 106 auditory neuropathy patients(212 ears) accepted auditory testing of pure tone audiometry(PTA), acoustic immitance,maximum speech recognition score(PBmax), distortion product otoacoustic emission(DPOAE), auditory brain response(ABR), electrocochleogram (ECochG), 40Hz auditory event-related potential(40HzAERP) and auditory steady-state responses(ASSR). Analyzed the correlation between PBmax and other testing results with software of PASW Sta- tistics 18.0. Results In auditory neuropathy patients, the results of PBmax testing present negative correlation with 40HzAERP and ASSR(P〈0.05). In 212 ears(106 cases) that accepted ABR testing, only 12 ears(5.7%) shown poor repeatabili- ty ABR waves, and the threshold of testing all above 80dBnHL. The PBmax score in patients who present ABR waves had significant greater than whom did not record ABR(P〈0.05). Between different group patients that accepted ECochG testing, there displayed significant difference(P〈0.05). The groups of SP/AP amplitude ratio lower than 0.5 and between 0.5 and 1.0 showed the greatest PBmax scores. Conclusions There appeared close correlation between PBmax score and other objec- tive or subjective audiometry testing in auditory neuropathy patients. Those patients have lower - SP/AP amplitude ratio or record ABR waves would present greater PBmax score. The patients' pure tone hearing threshold curves and hearing loss levels both showed correlation with PBmax scores. The PBmax correlate to other audiometry testing to diagnose or assess auditory neuropathy patients. It has a certain value for auditory specialists and clinical physicians.