目的开发新型抗肿瘤药物。方法以苯甲酰丙酮、二硫化碳、1,2-二溴乙烷为起始原料,设计合成了两个新型含硫杂环双(β-二酮)配体(Ⅰa-Ⅰb)及其钛配合物(Ⅱa-Ⅱb)。结果合成得到的新型含硫杂环双(β-二酮)配体(Ⅰa-Ⅰb)及其钛配合物(Ⅱa-Ⅱb)通过元素分析、红外光谱1、HNMR、MS等手段对其进行了结构表征。结论此合成路线完全可行。
Objective For exploiting novel antibacterical agent.Methods The middle compounds(Ⅰa-Ⅰc) and title compounds(Ⅱa-Ⅱc)were synthesied with 1-Benzoylacetone,carbon disolfide and 1,2-dibromoethane.Results The structure and composition of the middle compounds(Ⅰa-Ⅰc) and title compounds(Ⅱa-Ⅱc)were elucidated on the basis of elemental analysis,IR,1H NMR,MS.Conclusions The synthetic routes are practical.