中文摘要：

目的探讨18F-FDG PET/CT在诊断淋巴瘤脾脏浸润中的应用价值。方法回顾经18 F-FDG PET/CT诊断为淋巴瘤脾脏浸润的42例患者,分析脾脏体积、病灶大小、病灶密度、病灶最大标准摄取值（SUVmax）和正常肝脏SUVmax。结果 42例淋巴瘤脾脏浸润的18F-FDG PET/CT表现分为3型,其中Ⅰ型（单纯弥漫型浸润）24例、Ⅱ型（单纯结节型浸润）13例,Ⅲ型（混合型浸润）5例。在淋巴瘤浸润脾脏病灶的SUVmax中,Ⅱ型、Ⅲ型〉Ⅰ型（P均〈0.05）,Ⅱ型与Ⅲ型差异无统计学意义。霍奇金病（HD）与非霍奇金淋巴瘤（NHL）、B细胞淋巴瘤与T细胞/NK细胞淋巴瘤、B细胞淋巴瘤与HD的脾脏浸润PET/CT分型差异均无统计学意义（P=0.07、0.18、0.17）;T细胞/NK细胞淋巴瘤与HD的脾脏浸润PET/CT分型差异有统计学意义（P=0.02）。结论 18F-FDG PET/CT诊断脾脏淋巴瘤浸润有明显优势,其表现以Ⅰ型和Ⅱ型为主;淋巴瘤浸润脾脏结节样病灶的18F-FDG摄取显著高于弥漫性病灶;T细胞/NK细胞淋巴瘤累及脾脏较HD更多表现为Ⅰ型。

英文摘要：

Objective To observe the value of 18F-FDG PET/CT in patients with spleen infiltration of lymphoma.Methods Forty-two patients diagnosed as spleen infiltration of lymphoma with 18F-FDG PET/CT were retrospectively analyzed.The spleen volume,size,density,maximal standardized uptake value（SUVmax） of the lesions in the spleen and the liver were analyzed.Results Three types of spleen infiltration were displayed with 18F-FDG PET/CT,including 24 patients of type Ⅰ（pure diffuse infiltration）,13 of type Ⅱ（pure nodular infiltration） and 5 of type Ⅲ（mixed infiltration）.SUVmax of splenic lesions in type Ⅱ and type Ⅲ were higher than that of type Ⅰ（both P0.05）,but there was no statistical difference between type Ⅱ and type Ⅲ.There was no statistical difference about PET/CT performances of spleen infiltration respectively between Hodgkin diseases（HD） and non-Hodgkin lymphoma（NHL）,B-cell lymphoma and T-cell/NK-cell lymphoma,nor between B-cell lymphoma and HD（P=0.07,0.18,0.17）,while significant difference was found between T-cell/NK-cell lymphoma and HD（P=0.02）.Conclusion 18F-FDG PET/CT has advantages in diagnosing spleen infiltration of lymphoma,which mainly display as type Ⅰ and type Ⅱ.18F-FDG uptake of nodular-like lesions was significantly higher than that of diffuse lesions in spleens when involved by lymphoma.Compared with HD,T-cell/NK-cell lymphoma involving spleen mostly showed as type Ⅰ.