中文摘要：

目的：观察左旋维生素C离子导入对皮肤的美白、祛皱作用及安全性。方法：招募20名健康受试者进行半侧（治疗侧）皮肤的治疗。每日一次左旋维生素C导入,连续14天,对侧导入基质水凝胶作为对照。于使用前、后不同时间点,检测皮肤颜色及角质层含水量并由医师及受试者分别进行疗效主观评分。结果：治疗侧黑素指数（melanin index,MI）和治疗前后的差值显著高于对照侧（P〈0.05）,而红斑指数（erythema index,EI）和含水量差值治疗侧与对照侧无明显区别。医师及受试者的主观评分均认定左旋维生素C可使皮肤美白、毛孔细致、皱纹减少。结论：左旋维生素C可安全而有效地改善皮肤色泽和质地。

英文摘要：

Objective To observe the whitening and anti-wrinkle effect and safety of topical L-ascorbic acid serum on periorbital skin. Methods Twenty healthy volunteers were recruited.They were treated with topical L-ascorbic acid serum on only one side of face for a consecutive 2 weeks,with the other side untreated as self-control. Before and after each procedure, skin color, texture and water content were measured with mexameter （melanin index, MI;erythema index, EI）and corneometer, individually.The global assessment was performed both by a blinded dermatologist and by all the volunteers. Results The mean change of MI value of the treated side was significantly higher than that of the control side. There was no big difference of the mean El and water content between the two sides. Both the dermatologist and the volunteers assessed that the topical L-ascorbic acid serum could whiten the skin, shrink the pore, and reduce the wrinkle, in the slight to moderate extent. Conclusion The topical L-ascorbic acid serum could be used in treating photoaging periorbital skin, without any side effects.