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中文摘要：
1993～2006年间分离鸡白痢沙门氏菌141株,通过抗生素敏感性试验测定其对三甲氧苄氨嘧啶(TMP)耐药性,并用PCR方法检测dfrA基因的流行及与Ⅰ类整合子的关系。141个分离株对TMP的耐药率为90.8%(128/141)。128株TMP耐药性沙门氏菌中检测到4种dfrA基因,即dfrA1、dfrA12、dfrA13和dfrA17。dfrA12和dfrA17基因广泛分布。PCR产物测序表明:所有dfrA1和dfrA17基因都位于Ⅰ类整合子中;而dfrA12和dfrA13基因与Ⅰ类整合子无关,主要通过接合性质粒发生转移。鸡白痢沙门氏菌中TMP耐药性居于首位,其主要原因是dfrA基因广泛由接合性质粒和Ⅰ类整合子携带。
英文摘要：
One-hundred and forty-one Salmonella pullorum isolates were collected from chickens with clinical signs of pullorum disease from 1993 to 2006 in China,and were analysed by antimicrobial susceptibility testing.The gene cassette in the classⅠintegrons were amplified by PCR.One-hundred and twenty-eight(90.8%)of the 141 isolates were found to be resistant to trimethoprim.Of the 128 trimethoprim-resistant isolates,four kinds of dfr genes were detected as follows: dfrA1,dfrA12,dfrA13 and dfrA17.PCR mapping analys...
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