目的:总结分析中医药防治老年性痴呆(AD)的临床治疗规律,了解中医药防治老年性痴呆的用药现状,为临床防治AD提供依据。方法:电子检索CBMdisc(1979—2010年)、CNKI(1979—2010年)、VIP(1989—2010年)和万方(1998—2010年),并辅以手工检索。收集相关临床研究性论文,选取疗效确切、处方完整的论文,建立数据库,并应用Excel和spss11.5软件进行统计分析。结果:175篇治疗老年性痴呆的论文中,临床治疗分为三类:基础方+辨证用药、未经辨证单独使用一首方剂治疗老年性痴呆、辨证论治治疗老年性痴呆;对其用药的研究表明补虚药、开窍安神药、活血化瘀药、祛痰药、利水渗湿药使用频率最多。结论:老年性痴呆治疗规律显示其治疗方剂、用药种类繁多,临床多用补虚药、活血化瘀药和开窍安神三类中药。早期老年性痴呆以及记忆力减退的患者首选药物包括:石菖蒲、远志、川芎、熟地黄、何首乌、丹参、黄芪、山茱萸、茯苓、郁金等。
Objective:To analyze the prevention and treatment of AD and understand Chinese drug situation of Alzheimer′s,providing the basis for the prevention and treatment of AD.Methods:Collection of relevant clinical research from CBMdisc(from 1979 to 2010),CNKI(from 1979 to 2010),VIP(from 1989 to 2010),WANFANG Database(from 1998 to 2010)was made.We also hand searched relevant journals.The effective and complete prescription clinical research articles were selected to establish a database.We used Excel and spss11.5 analysis software for statisticla analysis.Results:Treatment of Alzheimer′s disease in 175 papers was divided into three categories:basic formula+syndrome medication;a separate treatment of Alzheime′s disease prescription;the treatment based on syndrome differentiation.The research showed that tonic medicine,blood-activating and stasis-resolving medicine,resuscitation tranquilizing medicine,expectorant medicine,dampness-draining medicine were the most frequently used drugs.Conclusion:Alzheimer′s clinical studies show a wide range of prescription and medicine.Tonic medicine,blood-activating and stasis-resolving medicine and resuscitation tranquilizing medicine used frequently in clinic.Early Alzheimer′s disease and memory loss can be treated with Acorus gramineus,Radix polygalae,Rhizome of chuanxiong,Radix Rehmanniae preparata,Polygon-um multiflorum,Salvia miltiorrhiza,Astragalus,cornus,Poria cocos,Radix Curcumae Aromaticae,ect.