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中文摘要：
目的：探讨谷氨酸和γ-氨基丁酸在阿尔茨海默病（AD）发生、发展中的作用.方法：利用硫磺素S染色技术检测APPswe转基因小鼠脑内沉积的老年斑;免疫荧光技术标记正常及APPswe转基因小鼠海马发育过程中谷氨酸、γ-氨基丁酸（GABA）阳性细胞. 结果： 模型组小鼠海马CA1、CA3区以及齿状回谷氨酸阳性细胞的数量明显少于正常对照组,而海马各区的GABA阳性细胞在两者之间变化不明显.结论： 谷氨酸与GABA能神经元数量的改变与Aβ诱导的神经元凋亡以及AD的病理发生有关.
英文摘要：
Objective： To understand the relationship between excitatory or inhibitory neurotransmitters and Alzheimer＇s disease, changes of glutamatergic and GABAergic neurons in the hippocampus of APPswe transgenic mice were investigated. Methods： The mice from postnatal day 0 to postnatal day 360 were used in the study with the immunofluorescent labeling. Results： The glutamatergie neurons in the transgenic mice of postnatal 12 months were showed less than wild type mice at same age （P〈0. 05）, while the number of GABAergic neurons in the hippocampus had no obvious difference in statistical significance. Conclusion： Our results suggest that the deficit of glutamatergic and GABAergic neurons may be the results which Aβ induces synaptie and neuronal loss.
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