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中文摘要：
镉是一种极易在人体内蓄积的有毒元素,长期的生物蓄积和生物放大,会对机体产生一系列的损伤,其中,对心血管系统的损伤包括易造成动脉硬化、高血压和心肌病等。本文将镉在心血管损伤方面的毒作用的研究进展进行了总结,包括镉对心血管的氧化损伤,对心血管粘附因子的破坏,对心血管内皮细胞的功能和DNA损伤修复机制的破坏,以及对心血管内皮细胞凋亡的促进等,指出全面系统地研究镉对心血管损伤的毒作用的主要机制是未来研究的重要方向。
英文摘要：
Cadmium（Cd） is a cumulative heavy metal poison which may exert a wide variety of adverse effects on humans through bioconcentration and biomagnification processes.The cardiovascular injuries caused by Cd include atherosclerosis,hypertension and cadiomyopathy.This review aims to summarize the toxicological mechanism of Cd on cardiovascular system,including oxidative damage,adhesion molecules damage,damage to functions of vascular endothelial cells,damage to DNA repairing system,and promotion of apoptosis of vascular endothelial cells.Conducting a systematic research on the toxicological mechanism of Cd-induced cardiovascular disease is suggested as one of the focuses of the future study in this area.
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