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兔胸主动脉在冻结状态下的断裂方式及其断裂判据的实验探讨
  • ISSN号:0258-8021
  • 期刊名称:《中国生物医学工程学报》
  • 时间:0
  • 分类:R318[医药卫生—生物医学工程;医药卫生—基础医学]
  • 作者机构:[1]上海理工大学低温医学与食品冷冻研究所,上海200093
  • 相关基金:国家自然科学基金重点项目(50436030);上海理工大学博士启动基金(X642);上海市重点学科(T0503)
中文摘要:

采用动态力学分析仪(DMA)研究温度、降温速率以及低温保护剂对冻结状态下兔胸主动脉的断裂方式的影响,并探讨其在冻结状态下断裂判据的确定方法.研究结果表明:均以5 ℃/min降温,主动脉在20 ℃时的轴向拉伸断裂方式表现为典型的韧性断裂,而温度达到-50 ℃或-80 ℃时,其断裂方式表现为典型的脆性断裂,其抗断裂能力随着温度降低而快速减弱;分别采用20 ℃/min和5 ℃/min降温到-50 ℃时,对主动脉的断裂方式影响不大,但对其抗断裂能力稍有影响;采用10%(V/V)二甲亚砜(DMSO)作低温保护剂,其断裂方式为典型的韧性断裂,抗断裂能力显著强于未经DMSO处理的血管;血管周向的抗断裂能力明显大于轴向,这可以解释为何主动脉血管冻存过程裂纹扩展方向一般与轴向垂直的现象.

英文摘要:

With Dynamical Mechanics Analysis (DMA), the effect of temperature, cooling rate and cryo-protective agent on the fracture modes of frozen rabbit aorta was investigated, and the determining method for crack criterion of frozen rabbit aorta was also discussed. The results showed that: with temperature decreasing, the fracture modes of frozen rabbit aorta were transformed from typical ductile fracture to typical brittle fracture, and its resist-fracture ability weakened remarkably from - 20℃ to - 80℃. The cooling rate exhibited little effects on the fracture modes when cooled to - 50 ℃, the resist-fracture ability of frozen rabbit aorta was stronger when the samples were pretreated at a higher cooling rate. Due to the hydration action of dimethyl sulphoxide ( DMSO), the rabbit aorta permeated by 10% (V/V). DMSO presented typical ductile fracture when cooled to -50℃, so its resist-fracture ability was enhanced obviously. The peripheral resist-fracture ability is higher than the axial one, which gave explanation of why the cracks of frozen rabbit aorta often present perpendicularly to the axial direction of rabbit aorta.

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期刊信息
  • 《中国生物医学工程学报》
  • 中国科技核心期刊
  • 主管单位:中国科学技术协会
  • 主办单位:中国生物医学工程学会
  • 主编:刘德培
  • 地址:北京东单三条9号
  • 邮编:100730
  • 邮箱:cjbmecjbme@163.com
  • 电话:010-65248786
  • 国际标准刊号:ISSN:0258-8021
  • 国内统一刊号:ISSN:11-2057/R
  • 邮发代号:82-73
  • 获奖情况:
  • 国内外数据库收录:
  • 被引量:8917