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临床肿瘤冷热疗过程中的热物理问题研究
  • 项目名称：临床肿瘤冷热疗过程中的热物理问题研究
  • 项目类别：重点项目
  • 批准号：50436030
  • 申请代码：E0603
  • 项目来源：国家自然科学基金
  • 研究期限：2005-01-01-2008-12-31
  • 项目负责人：徐学敏
  • 负责人职称：教授
  • 依托单位：上海交通大学
  • 批准年度：2004
中文摘要：

基于肿瘤发病率和死亡率的日益增加且常规治疗方法对患者产生的全身性副作用，本项目从获得临床最佳热物理肿瘤局部治疗方法的角度出发，通过理论与实验相结合的方法研究目前还未完全认识的肿瘤热物理治疗过程中的生物体损伤机理，如微循环的损伤、三维组织内冰晶形成与传播、热物理刺激产生的机体免疫响应等，并首次提出冷热交替治疗的方法，从细胞、组织和生物学效应的角度全面探索热物理对于生物体的作用机理，客观评价该肿瘤热物理治疗方法的安全性与有效性。

中文主题词： 肿瘤冷热疗;微循环损伤;免疫响应;动物实验;前期临床
成果综合统计
成果类型
数量
  • 期刊论文
  • 会议论文
  • 专利
  • 获奖
  • 著作
  • 91
  • 1
  • 0
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  • 4
期刊论文
冷冻过程细胞内水非平衡相变的研究
血液灌注和代谢产热温度依赖性对低温手术过程组织温度场的影响
低温手术过程多维传热有限元分析
用于批量快速筛选最佳低温保存程序的生物芯片技术
Water permeability parameters of dermal fibroblast employed in tissue engineering in subzero tempera
Response of Cytoskeleton of Murine Osteoblast Cultures to Two-step Freezing
Thermal analysis of tertiary butyl alcohol/sucrose/water ternary system
Cryopreservation of human embryonic stem cells: A protocol programmed cooling
Effects of freezing rates and dimethyl sulfoxide concentrations on thermal expansion of rabbit aorta
DSC study on the cooperative relaxation in 1, 2-propanediol
Freezing osteoblast cells attached to hydroxyapative discs and glass coverslips: Mechanisms of damge
Cryopreservation of tissue-engineered dermal replacement in Me2SO toxicity study and effects of conc
Numerical Simulation of Tissue Freezing by Liquid Nitrogen Based Cryoprobe
Study of heat shock response of human umbilical vein endothelial cells (HUVECs) using cDNA microarra
胞内冰晶形成（综述）
Study on tumor microvasculature damage induced by alternate cooling and heating
Energy-Based Diagnostic and Treatment Techniques—— Possible Applications for Early Detection and Tre
Morphological study of early-stage lung cancer using synchrotron radiation
Thermal stress study of two different artery cryopreservation methods
Development and performance test of a cryoprobe with heat transfer enhancement construction
Single-phase pressure drop and heat transfer characteristics of turbulent liquid nitrogen flow in mi
Flow boiling of liquid nitrogen in micro-tubes: Part I–The onset of nucleate boiling, two-phase flow
Feasibility study on using infrared thermometer for evaluation and administration of a cryosurgery,
兔主动脉冻结过程中未冻水份额的研究
饱和水溶液法制备磺胺甲噁唑的β-环糊精包合物研究
扑热息痛与β-环糊精包合物的热分解动力学和包合结构的研究
载入海藻糖红细胞冷冻干燥保存的实验研究
兔胸主动脉在冻结状态下的断裂方式及其断裂判据的实验探讨
红细胞冻干保存中的渗透性损伤实验研究
低温下脂肪在8-12GHz频率内的介电常数与电导率测量
海藻糖载入红细胞及其冷冻干燥的实验研究
Response of Cytoskeleton of Murine Osteoblast Cultures to Two-step Freezing
微通道中液氮的流动沸腾——两相流动压降分析
微通道中液氮的流动沸腾——换热特性分析
基于LabVIEW程序的血液透析实验系统
纳米超顺磁性铁氧体的制备与研究
温度、时间及葡萄糖加载对深低温（-15℃附近）冻存蚂蚁复活的影响
用DSC研究1，2-丙二醇及其水溶液的协同松弛行为
甘油对冷冻干燥保存红细胞抗氧化酶活性的影响
红外热图监测微波辐照式全身热疗中体表温度的变化
甘油预处理对红细胞冷冻干燥保存作用的实验研究
Me2SO浓度及预处理条件对组织工程化真皮活性的影响
Morphological study of endothelial cells during freezing
Cellular response of Murine Osteoblasts to Cryopreservation: the influence of attachment to Hydroxya
Numerical Study on the thawing process of biological tissue induced by laser irradiation
Numerical Study on Freezing Heat Transfer in cryosurgery with embedding Two Cryoprobes in Biological
Selective freezing of target biological tissues through injection of solutions with specific thermal
Disclosure of the significant thermal effects of large blood vessels during cryosurgery through infr
Numerical simulation of selective freezing of target biological tissues following injection of solut
Evaluation of Alternate Cooling and Heating for Tumor Treatment
Immunologic Response Induced by Synergistic Effect of Alternate Cooling and Heating of Breast Cancer
双冷针冷冻手术中冻结相变传热的数值模拟
微通道中液氮的流动沸腾：2. 换热特性分析
降温过程中组织工程用成纤维细胞膜水分渗透特性的实验研究
海藻糖和蛋黄在人类精子冻干保存中的保护作用
兔主动脉冻结膨胀行为及其影响因素的研究
Morphology study of freeze-drying mononuclear cells of human cord blood
冷刀手术时生物组织相变传热过程的数值模拟
生物组织冻结相变过程的数值模拟
3-D Numerical study on the Induced Heating Effects of embedded Micro/Nanoparticles on Human Body Sub
Numerical study on the effects of large blood vessels on 3-D tissue temperature profiles during cryo
丙三醇浓溶液Tg附近协同松弛的量热研究
用DSC 研究1,2-丙二醇及其水溶液的协同松弛行为
冻干保护剂溶液低温退火特性的研究
Effects of glycerol pretreatment on recovery and antioxidant enzyme activities of lyophilized red bl
Experimental study and analysis of mechanical properties of frozen rabbit aorta by fracture mechanic
Change of individual vascular endothelial calcium during hyperthermia
Experimental study of intracellular ice growth in human umbilical vein endothelial cells
Flow boiling of liquid nitrogen in micro-tubes: Part II–Heat transfer characteristics and critical h
Composition dependence of the Adam-Gibbs cooperative relaxation parameters in glycerol aqueous solut
Effects of two-step freeze on the ultra-structure of murine osteoblast cultures
Bioheat Transfer Model
生物组织的当量导热系数分析
肿瘤冻融相变传热过程的数值模拟
肿瘤低温治疗探针强化换热特性
微通道中液氮单相流动和换热实验研究
液氮流动沸腾换热研究综述
微通道中液氮的流动沸腾：1. 两相流动压降分析
Numerical study on freezing-thawing phase change heat transfer in biological tissue embedded with tw
Simulation of heat transfer of biological tissue during cryosurgery based on vascular trees
Theoretical analyses of thermal stress of blood vessel during cryopreservation
期刊论文共约90篇
低温下脂肪在8~12GHz频率内的介电常数与电导率测量,
冷冻干燥人红细胞复水时膜相变与复水损伤机理探讨
红细胞在保护剂添加和洗涤时的非平衡渗透响应实验研究
人胚胎干细胞程序降温保存的实验研究
冻干溶液的低温显微研究与热分析
冻结状态下主动脉裂纹扩展及断裂模式的研究
Measurement of the membrane elasticity of red blood cell with osmotic pressure by optical tweezers
Entropy generation theory for characterizing the freezing and thawing injury of biological materials
会议论文
A New Thermal System for Tumor Treatment
著作
低温生物医学工程学原理
“药品和食品的冷冻干燥”
冷冻干燥新技术
Freeze-drying of pharmaceutical and food products
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