中文摘要：

目的分析脑梗死（CI）患者血栓弹力图（TEG）AA抑制率与恢复期改良Rankin评分（m RS）的关系,辅助判断阿司匹林二级预防策略。方法选择2014年1月～2015年12月在上海交通大学医学院附属第九人民医院接受治疗的124例脑梗死患者,分为阿司匹林组（出院后坚持长期服用阿司匹林进行二级预防）79例和对照组（出院后未服用阿司匹林进行二级预防）44例,分别于90 d后和1年后评估m RS,分析长期服用阿司匹林进行二级预防对患者神经功能恢复的影响。每位患者于入院1周后进行TEG检测,包括AA抑制率。阿司匹林组79例患者中AA抑制率为0.00%～33.00%28例,〉33.00%～66.00%为16例,〉66.00%～100.00%为35例。随访在90 d和1年后不同m RS评分患者之间差别。结果发病后90 d评估发现,与对照组m RS[（3.68±2.14）分]比较,阿司匹林组m RS[（1.90±1.04）分]明显降低,差异有高度统计学意义（P〈0.01）;1年后评估,对照组为（3.30±2.51）分,阿司匹林组为（1.24±0.91）分,差异有高度统计学意义（P〈0.01）。不同AA抑制率患者90 d评估时m RS比较,差异有统计学意义（P〈0.05）,其中以AA抑制率〉33.00%～66.00%的患者m RS最低,神经功能恢复最好;1年后AA抑制率〉33.00%～66.00%的患者m RS最低,神经功能恢复最好。结论连续服用阿司匹林二级预防的脑梗死患者,无论是90 d后或者是1年后m RS评分明显降低,神经功能明显恢复。但AA抑制率并非越高越好,〉33.00%～66.00%的患者90 d后及1年后m RS均最低,神经功能恢复最好。

英文摘要：

Objective To analyze the relationship between the thrombelastogram（TEG） of AA inhibition rate and the modified Rankin score（m RS） in patients with cerebral infarction（CI）, in order to estimate the secondary prevention strategies with Aspirin. Methods From January 2014 to December 2015, in Ninth People＇s Hospital, School of Medicine,Shanghai Jiaotong University, 124 patients with cerebral infarction were selected and divided into two groups, Aspirin group（using Aspirin in secondary prevention after discharge, 79 cases） and control group（not using Aspirin in secondary prevention after discharge, 44 cases）, after 90 d and 1 year, the neural functional recovery influence of long period Aspirin intake was evaluated by m RS and the TEG, including the AA inhibition rate. Each patient was detected in one week after admission. Among 79 patients in Aspirin group, 28 cases were AA inhibition rate 0.00%-33.00%,〉33.00%-66.00% were 16 cases, 〉66.00%-100.00%were 35 cases, m RS of these patients was compared after90 d and 1 year. Results 90 days after the onset of CI,compared with control group [（3.68 ±2.14） scores], the m RS of Aspirin group [（1.90±1.04） scores] significantly reduced, the difference was statistically significant（P〈 0.01）; after 1 year, m RS of control group was（3.30 ±2.51）scores, m RS of Aspirin group was（1.24±0.91） scores, the difference was statistically significant（P〈 0.01）. After 90 d,the m RS of patients with different AA inhibition rate was compared, the difference was statistically significant（P〈 0.05）, the m RS of patients with AA inhibition rate 〉33.00%-66.00% was the lowest, recovery of neurological function was the best; after 1 year, the m RS of patients with AA inhibition rate 〉33.00%-66.00% was the lowest, recovery of neurological function was the best. Conclusion The patients continuously take Aspirin as secondary prevention of cerebral infarction, the m RS after 90 d or 1 year significantly reduce, neurological function signific