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中文摘要：
调节性免疫细胞具有广义和狭义概念,狭义上,调节性免疫细胞是指具有负性调节作用的免疫细胞。调节性B细胞（regulatory B cell,Breg）在控制炎症免疫相关疾病免疫应答、介导免疫耐受中可能发挥重要作用。Breg通过分泌抑制性细胞因子IL-10和TGF-β负性调控炎症免疫相关疾病的病理过程。TLRs/MyD88信号转导通路在介导Breg功能中起到关键作用。TLRs/MyD88信号转导活化促进Breg细胞产生IL-10,抑制T细胞活化及IFN-γ分泌。不同TLR控制着炎症免疫相关疾病的启动和恢复。运用优先触发Breg细胞调节功能的TLR激动剂,分离TLRs的相反作用,对控制免疫反应,制定合理的炎症免疫相关疾病治疗策略具有重要的意义。
英文摘要：
Regulatory immune cells have generalized and narrowed concepts.Regulatory immune cells are defined the cells with negative regulatory function in narrowed concepts.Regulatory B cell（Breg） plays an important role in controlling immune response,and mediating immune tolerance for inflammation and immune related diseases.Breg down-regulates the pathological progress of inflammation and immune related diseases through the inhibitory cytokines of IL-10 and TGF-β.TLRs/MyD88 signaling plays a key role in Breg function.The activation of TLRs/MyD88 signaling promotes IL-10 production and inhibits T cells activation and IFN-γ secretion.Different TLRs control the initiation and resumption.It will be significant for controlling immunoreaction,establishing rational therapeutic strategy of inflammation and immune related diseases by using TLR agonists to touch preferentially the regulating function of Breg,and separate oppositional function of TLRs.
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