欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
【目的】吡唑类化合物是一类具有广泛生物活性的化合物，为了寻找到高活性的杂环酰胺类化合物，对此类化合物做进一步研究。【方法】设计合成了12个N-（1，4-取代吡唑基）-吡啶酰胺类化合物；采用生长速率法，测试了化合物对小麦赤霉病菌（Gibberellazeae）、辣椒枯萎病菌（Fusariumoxysporum）和苹果腐烂病菌（Cytosporamandshurica）的抑制活性。【结果】初步生物活性表明：目标化合物在50mg／L质量浓度下对小麦赤霉病菌、辣椒枯萎病菌和苹果腐烂病菌有一定的抑制作用，其中化合物93对小麦赤霉病菌的抑制率达71．0％，化合物91对苹果腐烂病菌的抑制率达55．7％，具有进一步研究的价值。
英文摘要：
[Aims] Pyrazole derivates was a kind of compounds with high and broad-spectrum activity. In order to find heterocyclic carboxamide derivatives with high activity, and this kind of compounds were further studied. [Methods] A series of N-（1,4-disubstituted pyrazole-yl）-heterocyclic carboxamide derivatives were synthesized. All target compounds were bioassayed in vitro against three kinds of phytopathogenic fungi（Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica）. [Results] The preliminary results indicated most of the synthesized compounds possessed some antifungal activity against these three tested fungus at 50 mg/L, among which compounds 9j displayed 71.0% inhibition activities against G. zeae at 50 mg/L, and compounds 91 displayed 55.7% inhibition activities against C. mandshurica at 50 mg/L. The molecule structures of the target compounds could be optimized based on the designed compounds.
同期刊论文项目
同项目期刊论文
Organocatalytic Application of Enamine Intermediate. and Hydrogen Bonding Interaction to Dissymmetri
Synthesis and antibacterial activity of pyridinium-tailored 2,5-substituted-1,3,4-oxadiazole thioeth
Synthesis and Antifungal Activity of N-(Substituted pyridinyl)-1-methyl(phenyl)-3-(trifluoromethyl)-
Synthesis and Bioactivities of Novel1-(3-Chloropyridin-2-yl)-N-Substituted-5-(Trifluoromethyl)-Pyraz
期刊信息
位置：